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• W1665084893 abstract "Plant Dicer-like (DCL) enzymes exhibit a GC-preference during anti-viral post-transcriptional gene silencing (PTGS), delivering an evolutionary selection pressure resulting in plant viruses with GC-poor genomes. However, some viruses, e.g. Turnip Yellow Mosaic Virus (TYMV, genus Tymovirus) have GC-rich genomes, raising the question as to whether or not DCL derived selection pressure affects these viruses. In this study we analyzed the virus-derived small interfering RNAs from TYMV-infected leaves of Brassica juncea showed that the TYMV population accumulated a mutational bias with AU replacing GC (GC-AU), demonstrating PTGS pressure. Interestingly, at the highly polymorphic sites the GC-AU bias was no longer observed. This suggests the presence of an unknown mechanism preventing mutational drift of the viral population and maintaining viral genome stability, despite the host PTGS pressure." @default.
• W1665084893 created "2016-06-24" @default.
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• W1665084893 date "2015-12-01" @default.
• W1665084893 modified "2023-09-29" @default.
• W1665084893 title "Mutational bias of Turnip Yellow Mosaic Virus in the context of host anti-viral gene silencing" @default.
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• W1665084893 doi "https://doi.org/10.1016/j.virol.2015.08.024" @default.
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