Matches in SemOpenAlex for { <https://semopenalex.org/work/W166571842> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W166571842 endingPage "418" @default.
- W166571842 startingPage "407" @default.
- W166571842 abstract "Sensory endings of nerve fibers signalling joint pain express stretch-activated ion channels which open in response to an increase in membrane tension. These stretch-activated channels have been well characterised in Xenopus laevis oocytes. We have investigated whether hylan solutions of different elastoviscosity used for intra-articular treatment of joint pain in humans, modify the response characteristics of native stretch-activated ion channels of oocytes. Patch-clamp recordings on intact oocytes and in isolated membrane patches (outside-out) were performed in Barth's solution (control condition) and after exposure to hylans of different elastoviscosity. For mechanical stimulation, monitored suction was applied through the microelectrode and the activity of stretch-activated channels was recorded. The activity of the channels was significantly reduced in the presence of high elastoviscous hylan A, 0.9 % polymer content, molecular weight 6 M and of a mixture of hylan A (90% by weight) and hylan B (10% by weight 0.8% total polymer content), labelled as Synvisc®, a clinically used hylan product. In contrast, when a non-elastoviscous solution of hylan (hylan A, molecular weight 96, 000) was used, no effect was observed. In conclusion, stretch-activated channels have a decreased mechanical sensitivity in the presence of elastoviscous solutions of hylan, but not in the presence of non-elastoviscous solutions of hylan of the same concentration. These data suggest that the analgesic effect of intra-articular injection of elastoviscous solutions of hylans are due to a reduction of the sensitivity of joint mechano-nociceptors sensitivity in animals and in arthritic patients." @default.
- W166571842 created "2016-06-24" @default.
- W166571842 creator A5017665436 @default.
- W166571842 creator A5048895407 @default.
- W166571842 creator A5069047258 @default.
- W166571842 creator A5087861284 @default.
- W166571842 date "2002-01-01" @default.
- W166571842 modified "2023-09-27" @default.
- W166571842 title "EFFECTS OF ELASTOVISCOUS SOLUTIONS OF HYLURONAN DERIVATIVES ON MECHANOTRANSDUCTION" @default.
- W166571842 cites W1584457206 @default.
- W166571842 cites W185320283 @default.
- W166571842 cites W1881994315 @default.
- W166571842 cites W1972069797 @default.
- W166571842 cites W1979856671 @default.
- W166571842 cites W2002455415 @default.
- W166571842 cites W2020149988 @default.
- W166571842 cites W2023982143 @default.
- W166571842 cites W2029044221 @default.
- W166571842 cites W2036435359 @default.
- W166571842 cites W2063460492 @default.
- W166571842 cites W207481911 @default.
- W166571842 cites W2077425329 @default.
- W166571842 cites W2086354121 @default.
- W166571842 cites W2087209467 @default.
- W166571842 cites W2107903728 @default.
- W166571842 cites W2127841296 @default.
- W166571842 cites W2472910782 @default.
- W166571842 cites W2477129110 @default.
- W166571842 cites W2503813968 @default.
- W166571842 doi "https://doi.org/10.1533/9781845693121.407" @default.
- W166571842 hasPublicationYear "2002" @default.
- W166571842 type Work @default.
- W166571842 sameAs 166571842 @default.
- W166571842 citedByCount "1" @default.
- W166571842 crossrefType "book-chapter" @default.
- W166571842 hasAuthorship W166571842A5017665436 @default.
- W166571842 hasAuthorship W166571842A5048895407 @default.
- W166571842 hasAuthorship W166571842A5069047258 @default.
- W166571842 hasAuthorship W166571842A5087861284 @default.
- W166571842 hasConcept C12554922 @default.
- W166571842 hasConcept C126322002 @default.
- W166571842 hasConcept C136229726 @default.
- W166571842 hasConcept C15490471 @default.
- W166571842 hasConcept C169760540 @default.
- W166571842 hasConcept C170493617 @default.
- W166571842 hasConcept C172659308 @default.
- W166571842 hasConcept C181104049 @default.
- W166571842 hasConcept C185592680 @default.
- W166571842 hasConcept C24998067 @default.
- W166571842 hasConcept C50254741 @default.
- W166571842 hasConcept C55493867 @default.
- W166571842 hasConcept C71924100 @default.
- W166571842 hasConcept C86803240 @default.
- W166571842 hasConceptScore W166571842C12554922 @default.
- W166571842 hasConceptScore W166571842C126322002 @default.
- W166571842 hasConceptScore W166571842C136229726 @default.
- W166571842 hasConceptScore W166571842C15490471 @default.
- W166571842 hasConceptScore W166571842C169760540 @default.
- W166571842 hasConceptScore W166571842C170493617 @default.
- W166571842 hasConceptScore W166571842C172659308 @default.
- W166571842 hasConceptScore W166571842C181104049 @default.
- W166571842 hasConceptScore W166571842C185592680 @default.
- W166571842 hasConceptScore W166571842C24998067 @default.
- W166571842 hasConceptScore W166571842C50254741 @default.
- W166571842 hasConceptScore W166571842C55493867 @default.
- W166571842 hasConceptScore W166571842C71924100 @default.
- W166571842 hasConceptScore W166571842C86803240 @default.
- W166571842 hasLocation W1665718421 @default.
- W166571842 hasOpenAccess W166571842 @default.
- W166571842 hasPrimaryLocation W1665718421 @default.
- W166571842 hasRelatedWork W2085781026 @default.
- W166571842 hasRelatedWork W2186685714 @default.
- W166571842 hasRelatedWork W2771807434 @default.
- W166571842 hasRelatedWork W2805763177 @default.
- W166571842 hasRelatedWork W2973508371 @default.
- W166571842 hasRelatedWork W3006898855 @default.
- W166571842 hasRelatedWork W3031096035 @default.
- W166571842 hasRelatedWork W4309046853 @default.
- W166571842 hasRelatedWork W4319936555 @default.
- W166571842 hasRelatedWork W4319939153 @default.
- W166571842 isParatext "false" @default.
- W166571842 isRetracted "false" @default.
- W166571842 magId "166571842" @default.
- W166571842 workType "book-chapter" @default.