Matches in SemOpenAlex for { <https://semopenalex.org/work/W1665794041> ?p ?o ?g. }
- W1665794041 endingPage "183" @default.
- W1665794041 startingPage "119" @default.
- W1665794041 abstract "This chapter presents recent developments in the pharmacology of the benzodiazepines. The benzodiazepines are a class of compounds that have been found to show marked antianxiety effects in human subjects. Clinical studies indicate that various members of this series also have anticonvulsant, muscle relaxant, and hypnotic properties. In addition, there are reports of psychostimulant activity. New insights into the mechanism of action of the benzodiazepines have been provided by research published during the period 1967–1971:(1) The major muscle relaxant actions occur in the central nervous system. The primary effect seems to be a reduction in the facilitatory influence of the reticular formation on spinal reflexes. A direct action on the spinal cord may also occur. (2) Central modulation of autonomic responses may involve a discrete depressant effect on sympathetic vasoconstrictor activity. (3) A behavioral characteristic of benzodiazepines is the release of previously suppressed responses. Thus, before drug treatment rats learn to press a lever that produces a food reward, while ignoring a lever that produces no reward. During the action of chlordiazepoxide hydrochloride, the number of unrewarded responses is increased. This action is attributed to a breakdown of inhibition. (4) Electrophysiological studies in rats and cats indicate that a major action of benzodiazepines is on the hippocampus. This finding is in contrast to the action of barbiturates, which seem to act primarily on the brainstem reticular formation." @default.
- W1665794041 created "2016-06-24" @default.
- W1665794041 creator A5037949900 @default.
- W1665794041 creator A5048249105 @default.
- W1665794041 creator A5076382859 @default.
- W1665794041 date "1972-01-01" @default.
- W1665794041 modified "2023-09-25" @default.
- W1665794041 title "Recent Developments in the Pharmacology of the Benzodiazepines" @default.
- W1665794041 cites W1451067644 @default.
- W1665794041 cites W1880007343 @default.
- W1665794041 cites W1965502668 @default.
- W1665794041 cites W1973582371 @default.
- W1665794041 cites W1980147496 @default.
- W1665794041 cites W1980605265 @default.
- W1665794041 cites W1984087939 @default.
- W1665794041 cites W1988533047 @default.
- W1665794041 cites W1988592941 @default.
- W1665794041 cites W1991757350 @default.
- W1665794041 cites W1993464828 @default.
- W1665794041 cites W1993889800 @default.
- W1665794041 cites W1994464390 @default.
- W1665794041 cites W1995915134 @default.
- W1665794041 cites W1997102492 @default.
- W1665794041 cites W2000036156 @default.
- W1665794041 cites W2001219582 @default.
- W1665794041 cites W2002169109 @default.
- W1665794041 cites W2002425800 @default.
- W1665794041 cites W2004348581 @default.
- W1665794041 cites W2007350386 @default.
- W1665794041 cites W2014158422 @default.
- W1665794041 cites W2017339106 @default.
- W1665794041 cites W2018057222 @default.
- W1665794041 cites W2019308431 @default.
- W1665794041 cites W2021305575 @default.
- W1665794041 cites W2023668845 @default.
- W1665794041 cites W2024515959 @default.
- W1665794041 cites W2024774909 @default.
- W1665794041 cites W2024823352 @default.
- W1665794041 cites W2025782541 @default.
- W1665794041 cites W2028802103 @default.
- W1665794041 cites W2028822944 @default.
- W1665794041 cites W2031335530 @default.
- W1665794041 cites W2031478752 @default.
- W1665794041 cites W2032747448 @default.
- W1665794041 cites W2033317813 @default.
- W1665794041 cites W2034237046 @default.
- W1665794041 cites W2039602037 @default.
- W1665794041 cites W2039815178 @default.
- W1665794041 cites W2040032616 @default.
- W1665794041 cites W2040572900 @default.
- W1665794041 cites W2041436392 @default.
- W1665794041 cites W2043655320 @default.
- W1665794041 cites W2047431019 @default.
- W1665794041 cites W2050382274 @default.
- W1665794041 cites W2050868961 @default.
- W1665794041 cites W2050943299 @default.
- W1665794041 cites W2051675214 @default.
- W1665794041 cites W2053023658 @default.
- W1665794041 cites W2057071337 @default.
- W1665794041 cites W2057553230 @default.
- W1665794041 cites W2057751224 @default.
- W1665794041 cites W2059564752 @default.
- W1665794041 cites W2063158097 @default.
- W1665794041 cites W2066043389 @default.
- W1665794041 cites W2067830356 @default.
- W1665794041 cites W2068581889 @default.
- W1665794041 cites W2069701070 @default.
- W1665794041 cites W2070846125 @default.
- W1665794041 cites W2071393492 @default.
- W1665794041 cites W2075291589 @default.
- W1665794041 cites W2077354940 @default.
- W1665794041 cites W2078969050 @default.
- W1665794041 cites W2081914796 @default.
- W1665794041 cites W2082539307 @default.
- W1665794041 cites W2083394097 @default.
- W1665794041 cites W2091626648 @default.
- W1665794041 cites W2095126555 @default.
- W1665794041 cites W2132503932 @default.
- W1665794041 cites W2171906935 @default.
- W1665794041 cites W2282725145 @default.
- W1665794041 cites W2287371221 @default.
- W1665794041 cites W2334819647 @default.
- W1665794041 cites W2335657289 @default.
- W1665794041 cites W2404274155 @default.
- W1665794041 cites W2409775617 @default.
- W1665794041 cites W2444645420 @default.
- W1665794041 cites W84149720 @default.
- W1665794041 cites W987968720 @default.
- W1665794041 doi "https://doi.org/10.1016/s1054-3589(08)60523-2" @default.
- W1665794041 hasPublicationYear "1972" @default.
- W1665794041 type Work @default.
- W1665794041 sameAs 1665794041 @default.
- W1665794041 citedByCount "56" @default.
- W1665794041 crossrefType "book-chapter" @default.
- W1665794041 hasAuthorship W1665794041A5037949900 @default.
- W1665794041 hasAuthorship W1665794041A5048249105 @default.
- W1665794041 hasAuthorship W1665794041A5076382859 @default.
- W1665794041 hasConcept C15744967 @default.