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- W1665989742 abstract "There is a disconnect between FDA approvals for monotherapy or dual combination therapy in prophylaxis (based on superiority to placebo) and the clinical goals of achieving and maintaining long-term remission, which typically require more complicated treatment regimens, averaging three medications. This disconnect is particularly evident in the treatment of more representative patients with bipolar illness who often have several comorbidities, each requiring off-label prescription and assessment of treatment effectiveness that go beyond “evidence-based” guidelines. Systematic monitoring of mood, sleep, comorbidities, and side effects to evaluate effectiveness of medications and their combinations should be a critical component of psychotherapeutic/educational approaches to the illness. Other treatment principles for achieving better long-term outcomes are outlined in this chapter. Currently practiced routine care of patients with bipolar illness is often delayed and inadequate; a new era of more concerted research and rigorous treatment is required." @default.
- W1665989742 created "2016-06-24" @default.
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- W1665989742 date "2011-04-13" @default.
- W1665989742 modified "2023-09-26" @default.
- W1665989742 title "Complex Combination Therapy for Long‐Term Stability in Bipolar Disorder" @default.
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- W1665989742 doi "https://doi.org/10.1002/9780470975114.ch14" @default.
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