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- W1666231640 abstract "Abstract Experimentally induced, virally mediated oncogenesis has been used to study cancer for nearly 100 years. During this time, many of the fundamentals of cancer biology have been established. The technology differs from germline modification strategies in that the viral vectors that induce cancer in experimental animals achieve their goal by transferring genes into a limited number of somatic cells, usually after birth. New advances in these systems now support experimental designs aimed at assessing the effects of mixtures of genetic alterations, identification of the contribution of specific alterations on the histology of tumor cells, and the identification of cell‐of‐origin for certain cancers. These somatic cell gene transfer strategies are complementary to germline modification technologies in unraveling the complexities of cancer biology." @default.
- W1666231640 created "2016-06-24" @default.
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- W1666231640 date "2004-10-15" @default.
- W1666231640 modified "2023-10-12" @default.
- W1666231640 title "Somatic Cell Gene Transfer" @default.
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- W1666231640 doi "https://doi.org/10.1002/0471675067.mmc005" @default.
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