Matches in SemOpenAlex for { <https://semopenalex.org/work/W166640503> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W166640503 endingPage "12575" @default.
- W166640503 startingPage "12571" @default.
- W166640503 abstract "Abstract Platelets maintain a low cytosolic free Ca2+ concentration by limiting Ca2+ influx from plasma and promoting Ca2+ efflux. The present studies examine the role of the plasma membrane Na+ gradient in these processes. The Na+ gradient in intact unstimulated platelets was altered by incubating the platelets with ouabain or by replacing extracellular Na+ with N-methyl-D-glucamine or choline. Ca2+ flux across the plasma membrane and the amount of exchangeable Ca2+ in the platelet cytosol were measured by observing 45Ca2+ influx and efflux under steady-state conditions. The cytosolic free Ca2+ concentration was measured with the fluorescent probe quin2. At extracellular Na+ concentrations below 50 mM, the size of the cytosolic exchangeable Ca2+ pool increased by 48%. The size of the exchangeable Ca2+ pool sequestered in the dense tubular system increased by 356%. Ca2+ flux across the plasma membrane increased by 38%. There was, however, no change in total platelet Ca2+ and little, if any, change in the cytosolic free Ca2+ concentration. Similar effects were produced by incubating platelets with ouabain. These observations demonstrate a marked influence of the plasma membrane Na+ gradient on Ca2+ homeostasis in platelets. The nature of the changes, however, suggests that Na+/Ca2+ exchange cannot be sole basis for Ca2+ efflux from platelets." @default.
- W166640503 created "2016-06-24" @default.
- W166640503 creator A5066987101 @default.
- W166640503 date "1984-10-01" @default.
- W166640503 modified "2023-09-30" @default.
- W166640503 title "The effect of Na+ on Ca2+ homeostasis in unstimulated platelets." @default.
- W166640503 cites W114055788 @default.
- W166640503 cites W1489947307 @default.
- W166640503 cites W1501599308 @default.
- W166640503 cites W1516894702 @default.
- W166640503 cites W1522925775 @default.
- W166640503 cites W1536465820 @default.
- W166640503 cites W1547563617 @default.
- W166640503 cites W1594618806 @default.
- W166640503 cites W1596846507 @default.
- W166640503 cites W1964865306 @default.
- W166640503 cites W1967564284 @default.
- W166640503 cites W1976959646 @default.
- W166640503 cites W1982429234 @default.
- W166640503 cites W1986539156 @default.
- W166640503 cites W1996866713 @default.
- W166640503 cites W1998185507 @default.
- W166640503 cites W2010110152 @default.
- W166640503 cites W2012967091 @default.
- W166640503 cites W2029195069 @default.
- W166640503 cites W2039690331 @default.
- W166640503 cites W2045313496 @default.
- W166640503 cites W2064333892 @default.
- W166640503 cites W2065703248 @default.
- W166640503 cites W2065993385 @default.
- W166640503 cites W2075797460 @default.
- W166640503 cites W2415697340 @default.
- W166640503 cites W4210969856 @default.
- W166640503 cites W59094050 @default.
- W166640503 doi "https://doi.org/10.1016/s0021-9258(18)90785-4" @default.
- W166640503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6490631" @default.
- W166640503 hasPublicationYear "1984" @default.
- W166640503 type Work @default.
- W166640503 sameAs 166640503 @default.
- W166640503 citedByCount "59" @default.
- W166640503 countsByYear W1666405032012 @default.
- W166640503 countsByYear W1666405032013 @default.
- W166640503 crossrefType "journal-article" @default.
- W166640503 hasAuthorship W166640503A5066987101 @default.
- W166640503 hasBestOaLocation W1666405031 @default.
- W166640503 hasConcept C12554922 @default.
- W166640503 hasConcept C185592680 @default.
- W166640503 hasConcept C203014093 @default.
- W166640503 hasConcept C55493867 @default.
- W166640503 hasConcept C63645605 @default.
- W166640503 hasConcept C86803240 @default.
- W166640503 hasConcept C89560881 @default.
- W166640503 hasConcept C95444343 @default.
- W166640503 hasConceptScore W166640503C12554922 @default.
- W166640503 hasConceptScore W166640503C185592680 @default.
- W166640503 hasConceptScore W166640503C203014093 @default.
- W166640503 hasConceptScore W166640503C55493867 @default.
- W166640503 hasConceptScore W166640503C63645605 @default.
- W166640503 hasConceptScore W166640503C86803240 @default.
- W166640503 hasConceptScore W166640503C89560881 @default.
- W166640503 hasConceptScore W166640503C95444343 @default.
- W166640503 hasIssue "20" @default.
- W166640503 hasLocation W1666405031 @default.
- W166640503 hasOpenAccess W166640503 @default.
- W166640503 hasPrimaryLocation W1666405031 @default.
- W166640503 hasRelatedWork W1998646608 @default.
- W166640503 hasRelatedWork W2008483939 @default.
- W166640503 hasRelatedWork W2061936528 @default.
- W166640503 hasRelatedWork W2092770098 @default.
- W166640503 hasRelatedWork W2097656184 @default.
- W166640503 hasRelatedWork W2107712227 @default.
- W166640503 hasRelatedWork W2249877058 @default.
- W166640503 hasRelatedWork W2269713247 @default.
- W166640503 hasRelatedWork W2543366856 @default.
- W166640503 hasRelatedWork W2861500075 @default.
- W166640503 hasVolume "259" @default.
- W166640503 isParatext "false" @default.
- W166640503 isRetracted "false" @default.
- W166640503 magId "166640503" @default.
- W166640503 workType "article" @default.