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• W1666519766 abstract "A cytosolic thyroid-hormone-binding protein (xCTBP), predominantly responsible for the major binding activity of T3 in the cytosol of Xenopus liver, has been shown to be identical to aldehyde dehydrogenase class 1 (ALDH1) [Yamauchi, K., Nakajima, J., Hayashi, H., Horiuchi, R. & Tata, J.R. (1999) J. Biol. Chem. 274, 8460–8469]. Within this paper we surveyed which signaling, and other, compounds affect the thyroid hormone binding activity and aldehyde dehydrogenase activity of recombinant Xenopus ALDH1 (xCTBP/xALDH1) while examining the relationship between these two activities. NAD+ and NADH (each 200 µm), and two steroids (20 µm), inhibit significantly the T3-binding activity, while NADH and NADPH (each 200 µm), and iodothyronines (1 µm), inhibit the ALDH activity. Scatchard analysis and kinetic studies of xCTBP/xALDH1 indicate that NAD+ and T3 are noncompetitive inhibitors of thyroid-hormone-binding and ALDH activities, respectively. These results indicate the formation of a ternary complex consisting of the protein, NAD+ and thyroid hormone. Although the in vitro studies indicate that NAD+ and NADH markedly decrease T3-binding to xCTBP/xALDH1 at ≈ 10−4 m, a concentration equal to the NAD content in various Xenopus tissues, photoaffinity-labeling of [125I]T3 using cultured Xenopus cells demonstrates xCTBP/xALDH1 bound T3 within living cells. These results raise the possibility that an unknown factor(s) besides NAD+ and NADH may modulate the thyroid-hormone-binding activity of xCTBP/xALDH1. In comparison, thyroid hormone, at its physiological concentration, would poorly modulate the enzyme activity of xCTBP/xALDH1." @default.
• W1666519766 created "2016-06-24" @default.
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• W1666519766 date "2002-04-01" @default.
• W1666519766 modified "2023-09-26" @default.
• W1666519766 title "Effect of coenzymes and thyroid hormones on the dual activities ofXenopuscytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity" @default.
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• W1666519766 doi "https://doi.org/10.1046/j.1432-1033.2002.02891.x" @default.
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