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- W1666751903 abstract "The 2002-2003 epidemic of SARS (severe acute respiratory syndrome) that killed nearly 10% of the more than 8000 infected people is probably the most thoroughly studied example of an animal virus “jumping” into humans. SARS coronavirus was caught in the act of adapting to humans, acquiring mutations in several genes that allowed it to be transmitted from person to person and cause lethal disease. Coronaviruses closely related to the human epidemic strains of SARS coronavirus were discovered in several wild animal species, including the Himalayan masked palm civet, in exotic meat markets in Southern China (1). By sequencing hundreds of SARS viral RNA genomes from humans and animals during and after the epidemic, mutations were identified that distinguish the species-specific strains (2). Which of these mutations account for the explosive and virulent SARS epidemic? Strong evidence implicates the viral spike glycoprotein as one major determinant of the species specificity of coronavirus infection (3). Infection is initiated by trimers of the ~200-kD spike glycoprotein on the coronavirus envelope. The trimers bind SARS virus particles to their specific receptor glycoprotein, angiotensin-converting enzyme 2 (ACE2), on the surface of host cells (4)." @default.
- W1666751903 created "2016-06-24" @default.
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- W1666751903 date "2005-09-16" @default.
- W1666751903 modified "2023-10-14" @default.
- W1666751903 title "Adaptation of SARS Coronavirus to Humans" @default.
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- W1666751903 doi "https://doi.org/10.1126/science.1118817" @default.
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