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W1666877512 startingPage "288" @default.
W1666877512 abstract "Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario suggests the provocative hypothesis that pharmacological modulation of clock-related proteins may be suitable as an effective anticancer strategy. In this review, we focus on the functions of the druggable circadian nuclear receptors, REV-ERBα and REV-ERBβ, in cancer cell survival and describe the potential development of small molecule compounds that modulate REV-ERB activity as novel anticancer therapeutics. In addition, we debate the use of circadian rhythm-based synthetic lethal approaches to identify yet unexplored anticancer strategies." @default.
W1666877512 created "2016-06-24" @default.
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W1666877512 creator A5084685210 @default.
W1666877512 date "2015-10-01" @default.
W1666877512 modified "2023-10-18" @default.
W1666877512 title "Circadian clock: Time for novel anticancer strategies?" @default.
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W1666877512 doi "https://doi.org/10.1016/j.phrs.2015.08.008" @default.
W1666877512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26319800" @default.
W1666877512 hasPublicationYear "2015" @default.
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