Matches in SemOpenAlex for { <https://semopenalex.org/work/W166709825> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W166709825 endingPage "105.33" @default.
- W166709825 startingPage "105.33" @default.
- W166709825 abstract "Abstract Human Vgamma2Vdeta2 T cells are depleted during HIV infection. The majority of cells in this population are CD4-negative and do not support productive HIV infection; the mechanism for depleting them remains unknown. We noted recently that macaques immunized with an HIV R5-tropic gp120, also experienced severe Vgamma2Vdelta2 T cell depletion. A subsequent in vitro study showed that several different R5-tropic gp120, including those from Bal, ADA, YU2 and CN54 strains, induced human Vgamma2Vdelta2 T cell death that was inhibited by a CCR5 binding antagonist (Maraviroc) and a Caspase 8 inhibitor. The Vgamma2Vdelta2 may be especially vulnerable to cell death because they express high levels of CCR5 that could be modulated by Rapamycin treatment with a consequent reduction in Env-mediated cell killing. We have observed R5-tropic gp120 induced Vgamma2Vdelta2 T cell depletion both in vivo and in vitro, which was mediated by CCR5 receptor and Caspase 8 signaling pathway. We have identified a potential mechanism for Vgamma2Vdelta2 T cell depletion in HIV disease." @default.
- W166709825 created "2016-06-24" @default.
- W166709825 creator A5042867325 @default.
- W166709825 creator A5060929582 @default.
- W166709825 creator A5079394027 @default.
- W166709825 date "2011-04-01" @default.
- W166709825 modified "2023-09-25" @default.
- W166709825 title "HIV Env-mediated, CCR5-dependent depletion of human Vgamma2Vdelta2 T cells (105.33)" @default.
- W166709825 doi "https://doi.org/10.4049/jimmunol.186.supp.105.33" @default.
- W166709825 hasPublicationYear "2011" @default.
- W166709825 type Work @default.
- W166709825 sameAs 166709825 @default.
- W166709825 citedByCount "0" @default.
- W166709825 crossrefType "journal-article" @default.
- W166709825 hasAuthorship W166709825A5042867325 @default.
- W166709825 hasAuthorship W166709825A5060929582 @default.
- W166709825 hasAuthorship W166709825A5079394027 @default.
- W166709825 hasConcept C12823836 @default.
- W166709825 hasConcept C13373296 @default.
- W166709825 hasConcept C1491633281 @default.
- W166709825 hasConcept C159047783 @default.
- W166709825 hasConcept C170493617 @default.
- W166709825 hasConcept C190283241 @default.
- W166709825 hasConcept C202751555 @default.
- W166709825 hasConcept C203014093 @default.
- W166709825 hasConcept C2776090121 @default.
- W166709825 hasConcept C2778899366 @default.
- W166709825 hasConcept C2908647359 @default.
- W166709825 hasConcept C3013748606 @default.
- W166709825 hasConcept C31573885 @default.
- W166709825 hasConcept C37044404 @default.
- W166709825 hasConcept C55493867 @default.
- W166709825 hasConcept C71924100 @default.
- W166709825 hasConcept C86803240 @default.
- W166709825 hasConcept C8891405 @default.
- W166709825 hasConcept C95444343 @default.
- W166709825 hasConcept C99454951 @default.
- W166709825 hasConceptScore W166709825C12823836 @default.
- W166709825 hasConceptScore W166709825C13373296 @default.
- W166709825 hasConceptScore W166709825C1491633281 @default.
- W166709825 hasConceptScore W166709825C159047783 @default.
- W166709825 hasConceptScore W166709825C170493617 @default.
- W166709825 hasConceptScore W166709825C190283241 @default.
- W166709825 hasConceptScore W166709825C202751555 @default.
- W166709825 hasConceptScore W166709825C203014093 @default.
- W166709825 hasConceptScore W166709825C2776090121 @default.
- W166709825 hasConceptScore W166709825C2778899366 @default.
- W166709825 hasConceptScore W166709825C2908647359 @default.
- W166709825 hasConceptScore W166709825C3013748606 @default.
- W166709825 hasConceptScore W166709825C31573885 @default.
- W166709825 hasConceptScore W166709825C37044404 @default.
- W166709825 hasConceptScore W166709825C55493867 @default.
- W166709825 hasConceptScore W166709825C71924100 @default.
- W166709825 hasConceptScore W166709825C86803240 @default.
- W166709825 hasConceptScore W166709825C8891405 @default.
- W166709825 hasConceptScore W166709825C95444343 @default.
- W166709825 hasConceptScore W166709825C99454951 @default.
- W166709825 hasIssue "1_Supplement" @default.
- W166709825 hasLocation W1667098251 @default.
- W166709825 hasOpenAccess W166709825 @default.
- W166709825 hasPrimaryLocation W1667098251 @default.
- W166709825 hasRelatedWork W1987695408 @default.
- W166709825 hasRelatedWork W1996529895 @default.
- W166709825 hasRelatedWork W2077087158 @default.
- W166709825 hasRelatedWork W2096784087 @default.
- W166709825 hasRelatedWork W2133303802 @default.
- W166709825 hasRelatedWork W2141457436 @default.
- W166709825 hasRelatedWork W2160733843 @default.
- W166709825 hasRelatedWork W2216960478 @default.
- W166709825 hasRelatedWork W2331261012 @default.
- W166709825 hasRelatedWork W2931523797 @default.
- W166709825 hasVolume "186" @default.
- W166709825 isParatext "false" @default.
- W166709825 isRetracted "false" @default.
- W166709825 magId "166709825" @default.
- W166709825 workType "article" @default.