Matches in SemOpenAlex for { <https://semopenalex.org/work/W1667162022> ?p ?o ?g. }
- W1667162022 endingPage "524" @default.
- W1667162022 startingPage "519" @default.
- W1667162022 abstract "Docetaxel is used for treatment of several solid malignancies. In this study, we aimed for predicting docetaxel clearance and docetaxel-induced neutropenia by developing several genetic models. Therefore, pharmacokinetic data and absolute neutrophil counts (ANCs) of 213 docetaxel-treated cancer patients were collected. Next, patients were genotyped for 1936 single nucleotide polymorphisms (SNPs) in 225 genes using the drug-metabolizing enzymes and transporters platform and thereafter split into two cohorts. The combination of SNPs that best predicted severe neutropenia or low clearance was selected in one cohort and validated in the other. Patients with severe neutropenia had lower docetaxel clearance than patients with ANCs in the normal range (P=0.01). Severe neutropenia was predicted with 70% sensitivity. True low clearance (1 s.d.<mean clearance) was identified in 80% of cases. These models however did not reach statistical significance. To improve the predictive value of these models, the addition of non-genetic influencing factors is needed." @default.
- W1667162022 created "2016-06-24" @default.
- W1667162022 creator A5031865542 @default.
- W1667162022 creator A5034477516 @default.
- W1667162022 creator A5041610986 @default.
- W1667162022 creator A5047240860 @default.
- W1667162022 creator A5047950538 @default.
- W1667162022 creator A5058951480 @default.
- W1667162022 creator A5065279964 @default.
- W1667162022 creator A5066926133 @default.
- W1667162022 creator A5068302495 @default.
- W1667162022 creator A5071991781 @default.
- W1667162022 creator A5074174053 @default.
- W1667162022 creator A5081436594 @default.
- W1667162022 date "2015-09-08" @default.
- W1667162022 modified "2023-09-25" @default.
- W1667162022 title "Role of genetic variation in docetaxel-induced neutropenia and pharmacokinetics" @default.
- W1667162022 cites W109255500 @default.
- W1667162022 cites W1503260903 @default.
- W1667162022 cites W1570757468 @default.
- W1667162022 cites W1606129292 @default.
- W1667162022 cites W1744721587 @default.
- W1667162022 cites W1974814035 @default.
- W1667162022 cites W1984689348 @default.
- W1667162022 cites W1996896581 @default.
- W1667162022 cites W2000789083 @default.
- W1667162022 cites W2016353182 @default.
- W1667162022 cites W2045111884 @default.
- W1667162022 cites W2047673200 @default.
- W1667162022 cites W2048726850 @default.
- W1667162022 cites W2049081729 @default.
- W1667162022 cites W2052949843 @default.
- W1667162022 cites W2091666474 @default.
- W1667162022 cites W2094443974 @default.
- W1667162022 cites W2095993519 @default.
- W1667162022 cites W2112446953 @default.
- W1667162022 cites W2114826333 @default.
- W1667162022 cites W2114855290 @default.
- W1667162022 cites W2117284625 @default.
- W1667162022 cites W2131443715 @default.
- W1667162022 cites W2137475682 @default.
- W1667162022 cites W2139614539 @default.
- W1667162022 cites W2144205436 @default.
- W1667162022 cites W2154157379 @default.
- W1667162022 cites W2159744597 @default.
- W1667162022 cites W2166615754 @default.
- W1667162022 cites W2171698773 @default.
- W1667162022 cites W2293035635 @default.
- W1667162022 cites W2317457289 @default.
- W1667162022 doi "https://doi.org/10.1038/tpj.2015.66" @default.
- W1667162022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26345519" @default.
- W1667162022 hasPublicationYear "2015" @default.
- W1667162022 type Work @default.
- W1667162022 sameAs 1667162022 @default.
- W1667162022 citedByCount "17" @default.
- W1667162022 countsByYear W16671620222015 @default.
- W1667162022 countsByYear W16671620222018 @default.
- W1667162022 countsByYear W16671620222019 @default.
- W1667162022 countsByYear W16671620222020 @default.
- W1667162022 countsByYear W16671620222021 @default.
- W1667162022 countsByYear W16671620222022 @default.
- W1667162022 crossrefType "journal-article" @default.
- W1667162022 hasAuthorship W1667162022A5031865542 @default.
- W1667162022 hasAuthorship W1667162022A5034477516 @default.
- W1667162022 hasAuthorship W1667162022A5041610986 @default.
- W1667162022 hasAuthorship W1667162022A5047240860 @default.
- W1667162022 hasAuthorship W1667162022A5047950538 @default.
- W1667162022 hasAuthorship W1667162022A5058951480 @default.
- W1667162022 hasAuthorship W1667162022A5065279964 @default.
- W1667162022 hasAuthorship W1667162022A5066926133 @default.
- W1667162022 hasAuthorship W1667162022A5068302495 @default.
- W1667162022 hasAuthorship W1667162022A5071991781 @default.
- W1667162022 hasAuthorship W1667162022A5074174053 @default.
- W1667162022 hasAuthorship W1667162022A5081436594 @default.
- W1667162022 hasBestOaLocation W16671620221 @default.
- W1667162022 hasConcept C104317684 @default.
- W1667162022 hasConcept C112705442 @default.
- W1667162022 hasConcept C126322002 @default.
- W1667162022 hasConcept C135763542 @default.
- W1667162022 hasConcept C143998085 @default.
- W1667162022 hasConcept C153209595 @default.
- W1667162022 hasConcept C2776694085 @default.
- W1667162022 hasConcept C2777063308 @default.
- W1667162022 hasConcept C2781190966 @default.
- W1667162022 hasConcept C54355233 @default.
- W1667162022 hasConcept C71924100 @default.
- W1667162022 hasConcept C72563966 @default.
- W1667162022 hasConcept C86803240 @default.
- W1667162022 hasConcept C98274493 @default.
- W1667162022 hasConceptScore W1667162022C104317684 @default.
- W1667162022 hasConceptScore W1667162022C112705442 @default.
- W1667162022 hasConceptScore W1667162022C126322002 @default.
- W1667162022 hasConceptScore W1667162022C135763542 @default.
- W1667162022 hasConceptScore W1667162022C143998085 @default.
- W1667162022 hasConceptScore W1667162022C153209595 @default.
- W1667162022 hasConceptScore W1667162022C2776694085 @default.
- W1667162022 hasConceptScore W1667162022C2777063308 @default.
- W1667162022 hasConceptScore W1667162022C2781190966 @default.