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• W1667367966 endingPage "9597" @default.
• W1667367966 startingPage "9585" @default.
• W1667367966 abstract "Large-conductance Ca 2+ -activated K + channels (BK, also called Maxi-K or Slo channels) are widespread in the vertebrate nervous system, but their functional roles in synaptic transmission in the mammalian brain are largely unknown. By combining electrophysiology and immunogold cytochemistry, we demonstrate the existence of functional BK channels in presynaptic terminals in the hippocampus and compare their functional roles in somata and terminals of CA3 pyramidal cells. Double-labeling immunogold analysis with BK channel and glutamate receptor antibodies indicated that BK channels are targeted to the presynaptic membrane facing the synaptic cleft in terminals of Schaffer collaterals in stratum radiatum. Whole-cell, intracellular, and field-potential recordings from CA1 pyramidal cells showed that the presynaptic BK channels are activated by calcium influx and can contribute to repolarization of the presynaptic action potential (AP) and negative feedback control of Ca 2+ influx and transmitter release. This was observed in the presence of 4-aminopyridine (4-AP, 40–100 μ m ), which broadened the presynaptic compound action potential. In contrast, the presynaptic BK channels did not contribute significantly to regulation of action potentials or transmitter release under basal experimental conditions, i.e., without 4-AP, even at high stimulation frequencies. This is unlike the situation in the parent cell bodies (CA3 pyramidal cells), where BK channels contribute strongly to action potential repolarization. These results indicate that the functional role of BK channels depends on their subcellular localization." @default.
• W1667367966 created "2016-06-24" @default.
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• W1667367966 date "2001-12-15" @default.
• W1667367966 modified "2023-09-27" @default.
• W1667367966 title "Presynaptic Ca²⁺-Activated K⁺Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release" @default.
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• W1667367966 doi "https://doi.org/10.1523/jneurosci.21-24-09585.2001" @default.
• W1667367966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763057" @default.
• W1667367966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11739569" @default.
• W1667367966 hasPublicationYear "2001" @default.
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