Matches in SemOpenAlex for { <https://semopenalex.org/work/W166750816> ?p ?o ?g. }
- W166750816 endingPage "343" @default.
- W166750816 startingPage "329" @default.
- W166750816 abstract "Plasma membrane protein Na(+)/Ca(2+) exchanger (NCX) in vascular smooth muscle (VSM) cells plays an important role in intracellular Ca(2+) homeostasis, Ca(2+) signaling, and arterial contractility. Recent evidence in intact animals reveals that VSM NCX type 1 (NCX1) is importantly involved in the control of arterial blood pressure (BP) in the normal state and in hypertension. Increased expression of vascular NCX1 has been implicated in human primary pulmonary hypertension and several salt-dependent hypertensive animal models. Our aim is to determine the molecular and physiological mechanisms by which vascular NCX influences vasoconstriction and BP normally and in salt-dependent hypertension. Here, we describe the relative contribution of VSM NCX1 to Ca(2+) signaling and arterial contraction, including recent data from transgenic mice (NCX1(smTg/Tg), overexpressors; NCX1(sm-/-), knockouts) that has begun to elucidate the specific contributions of NCX to BP regulation. Arterial contraction and BP correlate with the level of NCX1 expression in smooth muscle: NCX1(sm-/-) mice have decreased arterial myogenic tone (MT), vasoconstriction, and low BP. NCX1(smTg/Tg) mice have high BP and are more sensitive to salt; their arteries exhibit upregulated transient receptor potential canonical channel 6 (TRPC6) protein, increased MT, and vasoconstriction. These observations suggest that NCX is a key component of certain distinct signaling pathways that activate VSM contraction in response to stretch (i.e., myogenic response) and to activation of certain G-protein-coupled receptors. Arterial NCX expression and mechanisms that control the local (sub-plasma membrane) Na(+) gradient, including cation-selective receptor-operated channels containing TRPC6, regulate arterial Ca(2+) and constriction, and thus BP." @default.
- W166750816 created "2016-06-24" @default.
- W166750816 creator A5055174519 @default.
- W166750816 date "2012-10-25" @default.
- W166750816 modified "2023-09-24" @default.
- W166750816 title "New Insights into the Contribution of Arterial NCX to the Regulation of Myogenic Tone and Blood Pressure" @default.
- W166750816 cites W1455833751 @default.
- W166750816 cites W1501757815 @default.
- W166750816 cites W1505906325 @default.
- W166750816 cites W1507203601 @default.
- W166750816 cites W1507851000 @default.
- W166750816 cites W1513222164 @default.
- W166750816 cites W1965021019 @default.
- W166750816 cites W1965543995 @default.
- W166750816 cites W1967247651 @default.
- W166750816 cites W1970260922 @default.
- W166750816 cites W1975700762 @default.
- W166750816 cites W1986089886 @default.
- W166750816 cites W1987651912 @default.
- W166750816 cites W1993074454 @default.
- W166750816 cites W1994218438 @default.
- W166750816 cites W1995512256 @default.
- W166750816 cites W1995757728 @default.
- W166750816 cites W1998388042 @default.
- W166750816 cites W2001858748 @default.
- W166750816 cites W2011025084 @default.
- W166750816 cites W2019832656 @default.
- W166750816 cites W2023675579 @default.
- W166750816 cites W2030303837 @default.
- W166750816 cites W2031135926 @default.
- W166750816 cites W2036082842 @default.
- W166750816 cites W2036631664 @default.
- W166750816 cites W2036948652 @default.
- W166750816 cites W2040514438 @default.
- W166750816 cites W2044862663 @default.
- W166750816 cites W2049507498 @default.
- W166750816 cites W2050553080 @default.
- W166750816 cites W2053907473 @default.
- W166750816 cites W2058778390 @default.
- W166750816 cites W2059201211 @default.
- W166750816 cites W2059462860 @default.
- W166750816 cites W2065992183 @default.
- W166750816 cites W2068595881 @default.
- W166750816 cites W2068615953 @default.
- W166750816 cites W2069465345 @default.
- W166750816 cites W2070299704 @default.
- W166750816 cites W2071127152 @default.
- W166750816 cites W2071160971 @default.
- W166750816 cites W2078738635 @default.
- W166750816 cites W2079448952 @default.
- W166750816 cites W2081513681 @default.
- W166750816 cites W2087106497 @default.
- W166750816 cites W2088140639 @default.
- W166750816 cites W2089519104 @default.
- W166750816 cites W2090221432 @default.
- W166750816 cites W2093412348 @default.
- W166750816 cites W2096838646 @default.
- W166750816 cites W2099618977 @default.
- W166750816 cites W2101722224 @default.
- W166750816 cites W2108844725 @default.
- W166750816 cites W2110401779 @default.
- W166750816 cites W2110651833 @default.
- W166750816 cites W2119185830 @default.
- W166750816 cites W2120082015 @default.
- W166750816 cites W2122717958 @default.
- W166750816 cites W2124380794 @default.
- W166750816 cites W2126657731 @default.
- W166750816 cites W2127390507 @default.
- W166750816 cites W2131734611 @default.
- W166750816 cites W2134939493 @default.
- W166750816 cites W2135068360 @default.
- W166750816 cites W2138742704 @default.
- W166750816 cites W2139379183 @default.
- W166750816 cites W2140577781 @default.
- W166750816 cites W2145824488 @default.
- W166750816 cites W2149619346 @default.
- W166750816 cites W2153726188 @default.
- W166750816 cites W2156600279 @default.
- W166750816 cites W2156773851 @default.
- W166750816 cites W2158762300 @default.
- W166750816 cites W2160683414 @default.
- W166750816 cites W2161431763 @default.
- W166750816 cites W2164074291 @default.
- W166750816 cites W2164186142 @default.
- W166750816 cites W2166521948 @default.
- W166750816 cites W2168142651 @default.
- W166750816 cites W2169784899 @default.
- W166750816 cites W2183681444 @default.
- W166750816 cites W2184759784 @default.
- W166750816 cites W2185777508 @default.
- W166750816 cites W2208409969 @default.
- W166750816 cites W2322058120 @default.
- W166750816 cites W2333436321 @default.
- W166750816 cites W2335815721 @default.
- W166750816 cites W2339804370 @default.
- W166750816 cites W2340062477 @default.
- W166750816 cites W2397778300 @default.
- W166750816 cites W2412432351 @default.