Matches in SemOpenAlex for { <https://semopenalex.org/work/W1667594920> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1667594920 endingPage "159" @default.
- W1667594920 startingPage "151" @default.
- W1667594920 abstract "A serious limitation of chemotherapy for acute myeloid leukaemia (AML), Hodgkins disease and some classes of breast cancer is that, even when clinically evident disease responds well, the same chemotherapy when given during remission does not affect the rate of relapse after chemotherapeutic or surgical ablation of the primary disease. This cannot, in general, be caused by genetic adaptation of the residual cancer cells which renders them resistant to specific drugs, because after relapse further remissions can be obtained with the same drugs that were ineffective by chronic administration in prolonging remission. The resistance of the residual cells may arise from mechanisms such as inaccessibility for anatomical or other reasons, or because of a change in metabolic state which causes these cells temporarily to cease division, when they cannot be harmed by cycle-dependent drugs and repair damage sustained from cycle-independent drugs. Limited differentiation has been shown capable of reversal and this may be a mechanism which leads to quiescence and associated “resistance”, particularly in the case of AML. Where such resistance occurs treatment during remission—or as an adjuvant to surgery and radiotherapy—may have to rely on mechanisms which are independent of cellular proliferation such as processes associated with graft-versus-host-disease or the induction of terminal differentiation. A model for studying the nature of resistance of residual cancer and for testing treatments that might be active against cancer cells in this state may be dormant metastases. The latter are malignant cells which appear to be in peaceful co-existence with their host and which in experimental systems have been induced to grow into lethal metastases by perturbation of the host by surgical trauma, by hormonal manipulation or by immunosuppression." @default.
- W1667594920 created "2016-06-24" @default.
- W1667594920 creator A5066327001 @default.
- W1667594920 date "1982-08-01" @default.
- W1667594920 modified "2023-10-08" @default.
- W1667594920 title "2nd Gordon Hamilton Fairley Lecture" @default.
- W1667594920 cites W1592955971 @default.
- W1667594920 cites W1976612692 @default.
- W1667594920 cites W1984679223 @default.
- W1667594920 cites W1987539795 @default.
- W1667594920 cites W1990823541 @default.
- W1667594920 cites W2018968119 @default.
- W1667594920 cites W2038808058 @default.
- W1667594920 cites W2060868446 @default.
- W1667594920 cites W2063165191 @default.
- W1667594920 cites W2065918804 @default.
- W1667594920 cites W2092316772 @default.
- W1667594920 cites W2149719802 @default.
- W1667594920 cites W2263949666 @default.
- W1667594920 cites W2414876646 @default.
- W1667594920 cites W2883367431 @default.
- W1667594920 cites W1815300979 @default.
- W1667594920 doi "https://doi.org/10.1038/bjc.1982.178" @default.
- W1667594920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2011078" @default.
- W1667594920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6960922" @default.
- W1667594920 hasPublicationYear "1982" @default.
- W1667594920 type Work @default.
- W1667594920 sameAs 1667594920 @default.
- W1667594920 citedByCount "15" @default.
- W1667594920 countsByYear W16675949202019 @default.
- W1667594920 crossrefType "journal-article" @default.
- W1667594920 hasAuthorship W1667594920A5066327001 @default.
- W1667594920 hasBestOaLocation W16675949201 @default.
- W1667594920 hasConcept C114851261 @default.
- W1667594920 hasConcept C121608353 @default.
- W1667594920 hasConcept C126322002 @default.
- W1667594920 hasConcept C143998085 @default.
- W1667594920 hasConcept C203014093 @default.
- W1667594920 hasConcept C2776694085 @default.
- W1667594920 hasConcept C2779134260 @default.
- W1667594920 hasConcept C502942594 @default.
- W1667594920 hasConcept C509974204 @default.
- W1667594920 hasConcept C71924100 @default.
- W1667594920 hasConcept C86803240 @default.
- W1667594920 hasConcept C89423630 @default.
- W1667594920 hasConcept C96232424 @default.
- W1667594920 hasConceptScore W1667594920C114851261 @default.
- W1667594920 hasConceptScore W1667594920C121608353 @default.
- W1667594920 hasConceptScore W1667594920C126322002 @default.
- W1667594920 hasConceptScore W1667594920C143998085 @default.
- W1667594920 hasConceptScore W1667594920C203014093 @default.
- W1667594920 hasConceptScore W1667594920C2776694085 @default.
- W1667594920 hasConceptScore W1667594920C2779134260 @default.
- W1667594920 hasConceptScore W1667594920C502942594 @default.
- W1667594920 hasConceptScore W1667594920C509974204 @default.
- W1667594920 hasConceptScore W1667594920C71924100 @default.
- W1667594920 hasConceptScore W1667594920C86803240 @default.
- W1667594920 hasConceptScore W1667594920C89423630 @default.
- W1667594920 hasConceptScore W1667594920C96232424 @default.
- W1667594920 hasIssue "2" @default.
- W1667594920 hasLocation W16675949201 @default.
- W1667594920 hasLocation W16675949202 @default.
- W1667594920 hasLocation W16675949203 @default.
- W1667594920 hasLocation W16675949204 @default.
- W1667594920 hasOpenAccess W1667594920 @default.
- W1667594920 hasPrimaryLocation W16675949201 @default.
- W1667594920 hasRelatedWork W1981900821 @default.
- W1667594920 hasRelatedWork W2089609493 @default.
- W1667594920 hasRelatedWork W2349204430 @default.
- W1667594920 hasRelatedWork W2378785636 @default.
- W1667594920 hasRelatedWork W2384708512 @default.
- W1667594920 hasRelatedWork W2387970634 @default.
- W1667594920 hasRelatedWork W2404042595 @default.
- W1667594920 hasRelatedWork W2417555288 @default.
- W1667594920 hasRelatedWork W3211657369 @default.
- W1667594920 hasRelatedWork W4304116770 @default.
- W1667594920 hasVolume "46" @default.
- W1667594920 isParatext "false" @default.
- W1667594920 isRetracted "false" @default.
- W1667594920 magId "1667594920" @default.
- W1667594920 workType "article" @default.