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- W1668356611 endingPage "BBI.S1075" @default.
- W1668356611 startingPage "BBI.S1075" @default.
- W1668356611 abstract "Using comparative genomics and in-silico analyses, we previously identified a new member of the prion-protein (PrP) family, the gene SPRN, encoding the protein Shadoo (Sho), and suggested its functions might overlap with those of PrP. Extended bioinformatics and conceptual biology studies to elucidate Sho's functions now reveal Sho has a conserved RGG-box motif, a well-known RNA-binding motif characterized in proteins such as FragileX Mental Retardation Protein. We report a systematic comparative analysis of RGG-box containing proteins which highlights the motif's functional versatility and supports the suggestion that Sho plays a dual role in cell signaling and RNA binding in brain. These findings provide a further link to PrP, which has well-characterized RNA-binding properties." @default.
- W1668356611 created "2016-06-24" @default.
- W1668356611 creator A5008289099 @default.
- W1668356611 creator A5029016040 @default.
- W1668356611 date "2008-01-01" @default.
- W1668356611 modified "2023-10-16" @default.
- W1668356611 title "Identification of the RGG Box Motif in Shadoo: RNA-Binding and Signaling Roles?" @default.
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