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• W1668510107 abstract "Neuronal activity in medial prefrontal cortex (mPFC) is critical for the formation of trace fear memory, yet the cellular mechanisms underlying these memories remain unclear. One possibility involves the modulation of intrinsic excitability within mPFC neurons that project to the basolateral complex of amygdala (BLA). The current study used a combination of retrograde labeling and in vitro whole-cell patch-clamp recordings to examine the effect of trace fear conditioning on the intrinsic excitability of layer 5 mPFC-BLA projection neurons in adult rats. Trace fear conditioning significantly enhanced the intrinsic excitability of regular spiking infralimbic (IL) projection neurons, as evidenced by an increase in the number of action potentials after current injection. These changes were also associated with a reduction in spike threshold and an increase in h current. In contrast, trace fear conditioning reduced the excitability of regular spiking prelimbic (PL) projection neurons, through a learning-related decrease of input resistance. Interestingly, the amount of conditioned freezing was (1) positively correlated with excitability of IL-BLA projection neurons after conditioning and (2) negatively correlated with excitability of PL-BLA projection neurons after extinction. Trace fear conditioning also significantly enhanced the excitability of burst spiking PL-BLA projection neurons. In both regions, conditioning-induced plasticity was learning specific (observed in conditioned but not in pseudoconditioned rats), flexible (reversed by extinction), and transient (lasted <10 d). Together, these data suggest that intrinsic plasticity within mPFC-BLA projection neurons occurs in a subregion- and cell-type-specific manner during acquisition, consolidation, and extinction of trace fear conditioning. Significance statement: Frontal lobe-related function is vital for a variety of important behaviors, some of which decline during aging. This study involves a novel combination of electrophysiological recordings from fluorescently labeled mPFC-to-amygdala projection neurons in rats with acquisition and extinction of trace fear conditioning to determine how specific neurons change during behavior. This is the first study to demonstrate that trace fear conditioning significantly alters the intrinsic excitability of mPFC-to-amygdala projection neurons in a subregion- and cell-type-specific manner, which is also transient and reversed by extinction. These data are of broad interest to the neuroscientific community, and the results will inspire additional studies investigating the cellular mechanisms underlying circuit-specific changes within the brain as a result of associative learning and memory." @default.
• W1668510107 created "2016-06-24" @default.
• W1668510107 creator A5050980920 @default.
• W1668510107 creator A5072830191 @default.
• W1668510107 creator A5090600373 @default.
• W1668510107 date "2015-09-30" @default.
• W1668510107 modified "2023-10-11" @default.
• W1668510107 title "Trace Fear Conditioning Differentially Modulates Intrinsic Excitability of Medial Prefrontal Cortex-Basolateral Complex of Amygdala Projection Neurons in Infralimbic and Prelimbic Cortices" @default.
• W1668510107 cites W106141043 @default.
• W1668510107 cites W1482138659 @default.
• W1668510107 cites W1527550792 @default.
• W1668510107 cites W1552650364 @default.
• W1668510107 cites W1635887916 @default.
• W1668510107 cites W1789081904 @default.
• W1668510107 cites W1877020112 @default.
• W1668510107 cites W1965655769 @default.
• W1668510107 cites W1975136983 @default.
• W1668510107 cites W1975341827 @default.
• W1668510107 cites W1977313055 @default.
• W1668510107 cites W1979166255 @default.
• W1668510107 cites W1982489283 @default.
• W1668510107 cites W1986287415 @default.
• W1668510107 cites W1987410185 @default.
• W1668510107 cites W1989513272 @default.
• W1668510107 cites W1992930205 @default.
• W1668510107 cites W1996307224 @default.
• W1668510107 cites W2000304680 @default.
• W1668510107 cites W2001082247 @default.
• W1668510107 cites W2011587435 @default.
• W1668510107 cites W2012483271 @default.
• W1668510107 cites W2017517270 @default.
• W1668510107 cites W2017675687 @default.
• W1668510107 cites W2019177723 @default.
• W1668510107 cites W2022670349 @default.
• W1668510107 cites W2024758252 @default.
• W1668510107 cites W2026823182 @default.
• W1668510107 cites W2027066461 @default.
• W1668510107 cites W2031167848 @default.
• W1668510107 cites W2037607749 @default.
• W1668510107 cites W2039506251 @default.
• W1668510107 cites W2040527392 @default.
• W1668510107 cites W2043048346 @default.
• W1668510107 cites W2050704896 @default.
• W1668510107 cites W2057563464 @default.
• W1668510107 cites W2062772815 @default.
• W1668510107 cites W2067976298 @default.
• W1668510107 cites W2068341253 @default.
• W1668510107 cites W2081090971 @default.
• W1668510107 cites W2082660854 @default.
• W1668510107 cites W2089413793 @default.
• W1668510107 cites W2090004056 @default.
• W1668510107 cites W2090490936 @default.
• W1668510107 cites W2093446419 @default.
• W1668510107 cites W2098070616 @default.
• W1668510107 cites W2106057704 @default.
• W1668510107 cites W2109839589 @default.
• W1668510107 cites W2111190823 @default.
• W1668510107 cites W2113226502 @default.
• W1668510107 cites W2114770633 @default.
• W1668510107 cites W2128984958 @default.
• W1668510107 cites W2130139021 @default.
• W1668510107 cites W2131141854 @default.
• W1668510107 cites W2136040261 @default.
• W1668510107 cites W2137350641 @default.
• W1668510107 cites W2137424929 @default.
• W1668510107 cites W2137500169 @default.
• W1668510107 cites W2137534843 @default.
• W1668510107 cites W2140404090 @default.
• W1668510107 cites W2146174151 @default.
• W1668510107 cites W2155158396 @default.
• W1668510107 cites W2158553737 @default.
• W1668510107 cites W2162153081 @default.
• W1668510107 cites W2162297383 @default.
• W1668510107 cites W2166252373 @default.
• W1668510107 cites W2167248961 @default.
• W1668510107 cites W2171154298 @default.
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• W1668510107 doi "https://doi.org/10.1523/jneurosci.2329-15.2015" @default.
• W1668510107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4588614" @default.
• W1668510107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26424895" @default.
• W1668510107 hasPublicationYear "2015" @default.
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