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- W1668678870 endingPage "e1005483" @default.
- W1668678870 startingPage "e1005483" @default.
- W1668678870 abstract "The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential regulation of the tandemly-duplicated long wavelength-sensitive (LWS) cone opsin genes. Zebrafish embryos were treated with RA from 48 hours post-fertilization (hpf) to 75 hpf, and RNA was isolated from eyes for microarray analysis. ~170 genes showed significantly altered expression, including several transcription factors and components of cellular signaling pathways. Of interest, the LWS1 opsin gene was strongly upregulated by RA. LWS1 is the upstream member of the tandemly duplicated LWS opsin array and is normally not expressed embryonically. Embryos treated with RA 48 hpf to 100 hpf or beyond showed significant reductions in LWS2-expressing cones in favor of LWS1-expressing cones. The LWS reporter line, LWS-PAC(H) provided evidence that individual LWS cones switched from LWS2 to LWS1 expression in response to RA. The RA signaling reporter line, RARE:YFP indicated that increased RA signaling in cones was associated with this opsin switch, and experimental reduction of RA signaling in larvae at the normal time of onset of LWS1 expression significantly inhibited LWS1 expression. A role for endogenous RA signaling in regulating differential expression of the LWS genes in postmitotic cones was further supported by the presence of an RA signaling domain in ventral retina of juvenile zebrafish that coincided with a ventral zone of LWS1 expression. This is the first evidence that an extracellular signal may regulate differential expression of opsin genes in a tandemly duplicated array." @default.
- W1668678870 created "2016-06-24" @default.
- W1668678870 creator A5005974704 @default.
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- W1668678870 creator A5023645976 @default.
- W1668678870 creator A5051795303 @default.
- W1668678870 creator A5091160141 @default.
- W1668678870 date "2015-08-21" @default.
- W1668678870 modified "2023-10-01" @default.
- W1668678870 title "Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish" @default.
- W1668678870 cites W1525882285 @default.
- W1668678870 cites W1555420746 @default.
- W1668678870 cites W1594569863 @default.
- W1668678870 cites W1599749709 @default.
- W1668678870 cites W1802167741 @default.
- W1668678870 cites W1902196155 @default.
- W1668678870 cites W1963847019 @default.
- W1668678870 cites W1971435386 @default.
- W1668678870 cites W1976261033 @default.
- W1668678870 cites W1976517931 @default.
- W1668678870 cites W1979756417 @default.
- W1668678870 cites W1979887680 @default.
- W1668678870 cites W1980397209 @default.
- W1668678870 cites W1980976351 @default.
- W1668678870 cites W1981264477 @default.
- W1668678870 cites W1982498248 @default.
- W1668678870 cites W1983159993 @default.
- W1668678870 cites W1983326313 @default.
- W1668678870 cites W1984382046 @default.
- W1668678870 cites W1987867074 @default.
- W1668678870 cites W1990355284 @default.
- W1668678870 cites W1991477688 @default.
- W1668678870 cites W1991923623 @default.
- W1668678870 cites W1992618284 @default.
- W1668678870 cites W1996121861 @default.
- W1668678870 cites W1996935145 @default.
- W1668678870 cites W1997588217 @default.
- W1668678870 cites W1997660442 @default.
- W1668678870 cites W1999608837 @default.
- W1668678870 cites W2000643824 @default.
- W1668678870 cites W2004652995 @default.
- W1668678870 cites W2007310728 @default.
- W1668678870 cites W2007631412 @default.
- W1668678870 cites W2008644341 @default.
- W1668678870 cites W2011078547 @default.
- W1668678870 cites W2012081529 @default.
- W1668678870 cites W2014328392 @default.
- W1668678870 cites W2014486607 @default.
- W1668678870 cites W2016237688 @default.
- W1668678870 cites W2016510463 @default.
- W1668678870 cites W2016694550 @default.
- W1668678870 cites W2016775890 @default.
- W1668678870 cites W2017754384 @default.
- W1668678870 cites W2021584737 @default.
- W1668678870 cites W2022593390 @default.
- W1668678870 cites W2025422774 @default.
- W1668678870 cites W2025698710 @default.
- W1668678870 cites W2026354673 @default.
- W1668678870 cites W2028574885 @default.
- W1668678870 cites W2028868015 @default.
- W1668678870 cites W2034013751 @default.
- W1668678870 cites W2035460899 @default.
- W1668678870 cites W2035700611 @default.
- W1668678870 cites W2036505824 @default.
- W1668678870 cites W2037749599 @default.
- W1668678870 cites W2039980265 @default.
- W1668678870 cites W2042080445 @default.
- W1668678870 cites W2046667570 @default.
- W1668678870 cites W2047213214 @default.
- W1668678870 cites W2048481264 @default.
- W1668678870 cites W2049573722 @default.
- W1668678870 cites W2054216757 @default.
- W1668678870 cites W2060315860 @default.
- W1668678870 cites W2064048040 @default.
- W1668678870 cites W2064234657 @default.
- W1668678870 cites W2065480479 @default.
- W1668678870 cites W2065501577 @default.
- W1668678870 cites W2067470032 @default.
- W1668678870 cites W2068620877 @default.
- W1668678870 cites W2070909031 @default.
- W1668678870 cites W2071215366 @default.
- W1668678870 cites W2071608659 @default.
- W1668678870 cites W2073626887 @default.
- W1668678870 cites W2075757902 @default.
- W1668678870 cites W2079001564 @default.
- W1668678870 cites W2081558031 @default.
- W1668678870 cites W2085738735 @default.
- W1668678870 cites W2088018354 @default.
- W1668678870 cites W2092047281 @default.
- W1668678870 cites W2095661228 @default.
- W1668678870 cites W2096561521 @default.
- W1668678870 cites W2100304031 @default.
- W1668678870 cites W2103728452 @default.
- W1668678870 cites W2104214722 @default.
- W1668678870 cites W2105279590 @default.
- W1668678870 cites W2107429793 @default.