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- W1668719079 abstract "Publisher Summary This chapter discusses the reviews published on chemistry, mode of action, and clinical use of various classes of antifungal agents. Topics of recent reviews are: fungal infection of the heart, fungal infections in the immuno-compromised host, systemic candida infections, mucor mycoses and agents for systemic treatment, and the role of fungi in the pathogenesis of human corneal ulcers. Approaches have been made to the diagnosis and therapy of dermatophytosis, onychomycosis and other fungal infections. New antifungal agents— oxiconazole, imidazole derivatives, RO 14-4767/002, and some others —their structure and activities against dermatophytes are discussed in detail in this chapter. The mode of action of antifungal drugs, with special reference to the imidazoles like 5-Fluorocytosine, Amphotericin B, Ketoconazole, Naftifine, Miconazole has been discussed in this chapter. Using differential scanning calorimetry it has been shown that high concentrations of Miconazole shift the lipid transition temperature of multilamellar vesicles to lower values without affecting the enthalpy of melting; Ketoconazole induces a broadening of the main transition peak only. The introduction of many topical antifungal agents and of an orally absorbed broad-spectrum antifungal drug represents important advances in antifungal chemotherapy." @default.
- W1668719079 created "2016-06-24" @default.
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- W1668719079 date "1980-01-01" @default.
- W1668719079 modified "2023-09-27" @default.
- W1668719079 title "Chapter 15. Antifungal Chemotherapy" @default.
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- W1668719079 doi "https://doi.org/10.1016/s0065-7743(08)60376-0" @default.
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