FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1669828090> ?p ?o ?g. }

• W1669828090 endingPage "3659" @default.
• W1669828090 startingPage "3653" @default.
• W1669828090 abstract "Cytotoxicity of human NK cells is activated by receptors that bind ligands on target cells, but the relative contribution of the many different activating and inhibitory NK cell receptors is difficult to assess. In this study, we describe an experimental system that circumvents some of the difficulties. Adhesion through beta2 integrin LFA-1 is a common requirement of CTLs and NK cells for efficient lysis of target cells. However, the contribution of LFA-1 to activation signals for NK cell cytotoxicity, besides its role in adhesion, is unclear. The role of LFA-1 was evaluated by exposing NK cells to human ICAM-1 that was either expressed on a Drosophila insect cell line, or directly coupled to beads. Expression of ICAM-1 on insect cells was sufficient to induce lysis by NK cells through LFA-1. Coexpression of peptide-loaded HLA-C with ICAM-1 on insect cells blocked the LFA-1-dependent cytotoxicity of NK cells that expressed HLA-C-specific inhibitory receptors. Polarization of cytotoxic granules in NK cells toward ICAM-1- and ICAM-2-coated beads showed that engagement of LFA-1 alone is sufficient to initiate activation signals in NK cells. Thus, in contrast to T cells, in which even adhesion through LFA-1 is dependent on signals from other receptors, NK cells receive early activation signals directly through LFA-1." @default.
• W1669828090 created "2016-06-24" @default.
• W1669828090 creator A5001347856 @default.
• W1669828090 creator A5036753241 @default.
• W1669828090 creator A5087340494 @default.
• W1669828090 date "2004-09-15" @default.
• W1669828090 modified "2023-10-12" @default.
• W1669828090 title "LFA-1 Contributes an Early Signal for NK Cell Cytotoxicity" @default.
• W1669828090 cites W1481604295 @default.
• W1669828090 cites W1568629805 @default.
• W1669828090 cites W1576773659 @default.
• W1669828090 cites W1631437819 @default.
• W1669828090 cites W1646315451 @default.
• W1669828090 cites W1873932476 @default.
• W1669828090 cites W1891201198 @default.
• W1669828090 cites W1913219728 @default.
• W1669828090 cites W1966056248 @default.
• W1669828090 cites W1970753581 @default.
• W1669828090 cites W1970788875 @default.
• W1669828090 cites W1983122237 @default.
• W1669828090 cites W1989046246 @default.
• W1669828090 cites W1989263689 @default.
• W1669828090 cites W1991992194 @default.
• W1669828090 cites W1995811820 @default.
• W1669828090 cites W1996717063 @default.
• W1669828090 cites W1999821664 @default.
• W1669828090 cites W2003976708 @default.
• W1669828090 cites W2009745195 @default.
• W1669828090 cites W2010358055 @default.
• W1669828090 cites W2020455973 @default.
• W1669828090 cites W2020639004 @default.
• W1669828090 cites W2030243462 @default.
• W1669828090 cites W2030546554 @default.
• W1669828090 cites W2031261181 @default.
• W1669828090 cites W2032125984 @default.
• W1669828090 cites W2032203698 @default.
• W1669828090 cites W2037883923 @default.
• W1669828090 cites W2044687503 @default.
• W1669828090 cites W2048743657 @default.
• W1669828090 cites W2050069950 @default.
• W1669828090 cites W2054275629 @default.
• W1669828090 cites W2054697569 @default.
• W1669828090 cites W2056254232 @default.
• W1669828090 cites W2059274772 @default.
• W1669828090 cites W2061097078 @default.
• W1669828090 cites W2064733298 @default.
• W1669828090 cites W2069767991 @default.
• W1669828090 cites W2079216908 @default.
• W1669828090 cites W2080683076 @default.
• W1669828090 cites W2081852845 @default.
• W1669828090 cites W2083618683 @default.
• W1669828090 cites W2083681059 @default.
• W1669828090 cites W2087655494 @default.
• W1669828090 cites W2098438673 @default.
• W1669828090 cites W2098930452 @default.
• W1669828090 cites W2101755457 @default.
• W1669828090 cites W2104317124 @default.
• W1669828090 cites W2104763928 @default.
• W1669828090 cites W2106756955 @default.
• W1669828090 cites W2118191267 @default.
• W1669828090 cites W2124171023 @default.
• W1669828090 cites W2124982785 @default.
• W1669828090 cites W2126618915 @default.
• W1669828090 cites W2130649175 @default.
• W1669828090 cites W2132226411 @default.
• W1669828090 cites W2133064156 @default.
• W1669828090 cites W2136542540 @default.
• W1669828090 cites W2147498336 @default.
• W1669828090 cites W2159180573 @default.
• W1669828090 cites W2168315486 @default.
• W1669828090 cites W4248990922 @default.
• W1669828090 cites W50224345 @default.
• W1669828090 doi "https://doi.org/10.4049/jimmunol.173.6.3653" @default.
• W1669828090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15356110" @default.
• W1669828090 hasPublicationYear "2004" @default.
• W1669828090 type Work @default.
• W1669828090 sameAs 1669828090 @default.
• W1669828090 citedByCount "271" @default.
• W1669828090 countsByYear W16698280902012 @default.
• W1669828090 countsByYear W16698280902013 @default.
• W1669828090 countsByYear W16698280902014 @default.
• W1669828090 countsByYear W16698280902015 @default.
• W1669828090 countsByYear W16698280902016 @default.
• W1669828090 countsByYear W16698280902017 @default.
• W1669828090 countsByYear W16698280902018 @default.
• W1669828090 countsByYear W16698280902019 @default.
• W1669828090 countsByYear W16698280902020 @default.
• W1669828090 countsByYear W16698280902021 @default.
• W1669828090 countsByYear W16698280902022 @default.
• W1669828090 countsByYear W16698280902023 @default.
• W1669828090 crossrefType "journal-article" @default.
• W1669828090 hasAuthorship W1669828090A5001347856 @default.
• W1669828090 hasAuthorship W1669828090A5036753241 @default.
• W1669828090 hasAuthorship W1669828090A5087340494 @default.
• W1669828090 hasBestOaLocation W16698280901 @default.
• W1669828090 hasConcept C109316439 @default.
• W1669828090 hasConcept C122871604 @default.
• W1669828090 hasConcept C129374314 @default.

• next