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• W1670158471 startingPage "11055" @default.
• W1670158471 abstract "Endogenous amines and peptides continuously modulate the activity of neuronal networks and are required even for their normal operation. The respiratory rhythm generator, localized in the pre-Bötzinger complex, is not an exception. This network is modulated by various neurotransmitters, including serotonin (5-HT). In this study, we isolated the respiratory network in brainstem slices and demonstrate that the endogenous activation of 5-HT_2A is required for the generation of the respiratory rhythm <i>in vitro</i>. At the network level, activation of 5-HT_2A receptors with 4-iodo-2,5-dimethoxyamphetamine or the 5-HT uptake blocker alaproclate increased the frequency of respiratory activity. Blockade of endogenously activated 5-HT_2A receptors with three different antagonists decreased the frequency, amplitude, and regularity of respiratory population activity, an effect that was blocked by protein kinase C (PKC) activators. At the cellular level, blockade of 5-HT_2A receptors reduced the action potential discharge in all examined respiratory neurons, which was associated with a reduction in the fast and the persistent sodium current. Continuous application of 5-HT_2A-receptor antagonists differentially affected pacemaker neurons. Pacemaker activity was eliminated in cadmium-insensitive pacemaker neurons. In cadmium-sensitive pacemaker neurons, the frequency of pacemaker activity was unaffected and the amplitude of pacemaker bursts was enhanced. It is assumed that cadmium-insensitive pacemakers rely on the persistent sodium current, whereas cadmium-sensitive pacemakers depend on the activation of calcium currents. We conclude that endogenously activated 5-HT_2A receptors are required for maintaining fictive respiratory activity in the brainstem slice by modulating sodium conductances via a PKC pathway." @default.
• W1670158471 created "2016-06-24" @default.
• W1670158471 creator A5010756785 @default.
• W1670158471 creator A5076853914 @default.
• W1670158471 date "2002-12-15" @default.
• W1670158471 modified "2023-09-29" @default.
• W1670158471 title "Endogenous Activation of Serotonin-2A Receptors Is Required for Respiratory Rhythm Generation<i>In Vitro</i>" @default.
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• W1670158471 doi "https://doi.org/10.1523/jneurosci.22-24-11055.2002" @default.
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