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• W1670760220 abstract "Research Article1 July 1992free access Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins. M. Scheffner M. Scheffner Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author K. Münger K. Münger Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author J.M. Huibregtse J.M. Huibregtse Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author P.M. Howley P.M. Howley Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author M. Scheffner M. Scheffner Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author K. Münger K. Münger Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author J.M. Huibregtse J.M. Huibregtse Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author P.M. Howley P.M. Howley Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. Search for more papers by this author Author Information M. Scheffner1, K. Münger1, J.M. Huibregtse1 and P.M. Howley1 1Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892. The EMBO Journal (1992)11:2425-2431https://doi.org/10.1002/j.1460-2075.1992.tb05307.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The E6 and the E7 proteins of the oncogenic human papillomavirus types 16 and 18 can stably associate with p53 and the retinoblastoma protein, respectively. The E6-p53 interaction results in the accelerated degradation of p53 in vitro via the ubiquitin-dependent proteolysis system. In this study we demonstrate that a fusion protein consisting of the N-terminal half of the HPV-16 E7 protein and the full length HPV-16 E6 protein promotes the in vitro degradation of the retinoblastoma protein. This indicates that the property of the HPV-16 E6 protein to stimulate the degradation of p53 can be targeted to other proteins. Unlike the HPV-16 or HPV-18 E6 protein, the E6 proteins of HPV-6 and 11 do not bind to p53 and consequently do not target p53 for degradation. Analogous E7-E6 fusion proteins using the E6 proteins of HPV-6 and HPV-11, however, also have the ability to promote the degradation of the retinoblastoma protein, indicating that the property to target associated proteins for degradation is shared by the anogenital specific HPV E6 proteins. Previous ArticleNext Article Volume 11Issue 71 July 1992In this issue RelatedDetailsLoading ..." @default.
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• W1670760220 date "1992-07-01" @default.
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• W1670760220 title "Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins." @default.
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• W1670760220 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05307.x" @default.
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