FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1671132870> ?p ?o ?g. }

• W1671132870 endingPage "5" @default.
• W1671132870 startingPage "1730" @default.
• W1671132870 abstract "The cyclin-dependent kinase inhibitor p27 is a negative regulator of the cell division cycle. It is expressed at the highest levels during the quiescent (G0) and prereplicative (G1) phases, and its degradation is required for entry into the S phase. Because lack of p27 is associated with aggressive behavior in a variety of tumors of epithelial and lymphoid origin, we used immunohistochemistry and in situ hybridization to evaluate the expression of p27 in metaplastic and dysplastic Barrett's epithelium and to assess its prognostic significance in Barrett's associated adenocarcinoma (BAA) of the esophagus. In metaplastic Barrett's epithelium, p27 protein and mRNA were restricted to the superficial third of glands in all cases and extended to the lower third in 4 cases. In contrast, expression of p27 message and protein was both increased and full-thickness, in the 23 cases with high-grade dysplasia adjacent to BAA and in carcinoma in situ. Although all invasive carcinomas had elevated levels of p27 mRNA, 45 (83%) of 54 invasive carcinomas had low p27 protein levels (<50% positive tumor cells). Low p27 protein correlated with higher histological grade (P < 0.0001), depth of invasion (P = 0.0120), presence of lymph node metastasis (P = 0.05), and survival (P = 0.0197). In addition to the nuclear staining, cytoplasmic staining of p27 was noted in 11 of 23 (48%) of cases of dysplasia and in 14 of 54 (26%) adenocarcinomas and confirmed, in a subset of cases, by subcellular fractionation of protein lysates obtained from fresh tumor tissues. Cytoplasmic localization of p27 was also associated with decreased survival (P = 0.0239). Loss of p27 conferred poor prognosis independently of proliferative index, as assessed by Ki-67 (MIB-1) immunostaining, which was not significantly different in survivors versus nonsurvivors. These results show that: (a) distribution of p27 message and protein parallel one another in metaplastic and dysplastic Barrett's epithelium, suggesting transcriptional regulation of the gene in the nonneoplastic setting; (b) p27 is inactivated in the majority of BAA as a result of either post-transcriptional modification or altered subcellular localization; and (c) loss of the cell cycle inhibitor p27 is associated with parameters of aggressive behavior and unfavorable outcome in BAA." @default.
• W1671132870 created "2016-06-24" @default.
• W1671132870 creator A5005649277 @default.
• W1671132870 creator A5006968921 @default.
• W1671132870 creator A5016531008 @default.
• W1671132870 creator A5034919044 @default.
• W1671132870 creator A5037209524 @default.
• W1671132870 creator A5046795494 @default.
• W1671132870 creator A5070136516 @default.
• W1671132870 creator A5071763026 @default.
• W1671132870 creator A5082899536 @default.
• W1671132870 creator A5090017091 @default.
• W1671132870 date "1998-04-15" @default.
• W1671132870 modified "2023-10-01" @default.
• W1671132870 title "Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma." @default.
• W1671132870 cites W1518721136 @default.
• W1671132870 cites W1527716720 @default.
• W1671132870 cites W1605741702 @default.
• W1671132870 cites W1650185154 @default.
• W1671132870 cites W1971254046 @default.
• W1671132870 cites W1972955523 @default.
• W1671132870 cites W1991494214 @default.
• W1671132870 cites W2021457628 @default.
• W1671132870 cites W2038318576 @default.
• W1671132870 cites W2084248932 @default.
• W1671132870 cites W2084810510 @default.
• W1671132870 cites W2091403769 @default.
• W1671132870 cites W2092654917 @default.
• W1671132870 cites W2094859123 @default.
• W1671132870 cites W2095256813 @default.
• W1671132870 cites W2044024251 @default.
• W1671132870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9563491" @default.
• W1671132870 hasPublicationYear "1998" @default.
• W1671132870 type Work @default.
• W1671132870 sameAs 1671132870 @default.
• W1671132870 citedByCount "103" @default.
• W1671132870 countsByYear W16711328702013 @default.
• W1671132870 countsByYear W16711328702014 @default.
• W1671132870 countsByYear W16711328702015 @default.
• W1671132870 countsByYear W16711328702016 @default.
• W1671132870 countsByYear W16711328702017 @default.
• W1671132870 countsByYear W16711328702018 @default.
• W1671132870 countsByYear W16711328702020 @default.
• W1671132870 countsByYear W16711328702022 @default.
• W1671132870 countsByYear W16711328702023 @default.
• W1671132870 crossrefType "journal-article" @default.
• W1671132870 hasAuthorship W1671132870A5005649277 @default.
• W1671132870 hasAuthorship W1671132870A5006968921 @default.
• W1671132870 hasAuthorship W1671132870A5016531008 @default.
• W1671132870 hasAuthorship W1671132870A5034919044 @default.
• W1671132870 hasAuthorship W1671132870A5037209524 @default.
• W1671132870 hasAuthorship W1671132870A5046795494 @default.
• W1671132870 hasAuthorship W1671132870A5070136516 @default.
• W1671132870 hasAuthorship W1671132870A5071763026 @default.
• W1671132870 hasAuthorship W1671132870A5082899536 @default.
• W1671132870 hasAuthorship W1671132870A5090017091 @default.
• W1671132870 hasConcept C104317684 @default.
• W1671132870 hasConcept C105580179 @default.
• W1671132870 hasConcept C105702510 @default.
• W1671132870 hasConcept C121608353 @default.
• W1671132870 hasConcept C142724271 @default.
• W1671132870 hasConcept C199835354 @default.
• W1671132870 hasConcept C204232928 @default.
• W1671132870 hasConcept C2775894508 @default.
• W1671132870 hasConcept C2777542201 @default.
• W1671132870 hasConcept C2777546739 @default.
• W1671132870 hasConcept C2777819096 @default.
• W1671132870 hasConcept C2780849966 @default.
• W1671132870 hasConcept C2781182431 @default.
• W1671132870 hasConcept C29537977 @default.
• W1671132870 hasConcept C30481170 @default.
• W1671132870 hasConcept C502942594 @default.
• W1671132870 hasConcept C529295009 @default.
• W1671132870 hasConcept C54355233 @default.
• W1671132870 hasConcept C55493867 @default.
• W1671132870 hasConcept C71924100 @default.
• W1671132870 hasConcept C74864618 @default.
• W1671132870 hasConcept C81439078 @default.
• W1671132870 hasConcept C86803240 @default.
• W1671132870 hasConceptScore W1671132870C104317684 @default.
• W1671132870 hasConceptScore W1671132870C105580179 @default.
• W1671132870 hasConceptScore W1671132870C105702510 @default.
• W1671132870 hasConceptScore W1671132870C121608353 @default.
• W1671132870 hasConceptScore W1671132870C142724271 @default.
• W1671132870 hasConceptScore W1671132870C199835354 @default.
• W1671132870 hasConceptScore W1671132870C204232928 @default.
• W1671132870 hasConceptScore W1671132870C2775894508 @default.
• W1671132870 hasConceptScore W1671132870C2777542201 @default.
• W1671132870 hasConceptScore W1671132870C2777546739 @default.
• W1671132870 hasConceptScore W1671132870C2777819096 @default.
• W1671132870 hasConceptScore W1671132870C2780849966 @default.
• W1671132870 hasConceptScore W1671132870C2781182431 @default.
• W1671132870 hasConceptScore W1671132870C29537977 @default.
• W1671132870 hasConceptScore W1671132870C30481170 @default.
• W1671132870 hasConceptScore W1671132870C502942594 @default.
• W1671132870 hasConceptScore W1671132870C529295009 @default.
• W1671132870 hasConceptScore W1671132870C54355233 @default.
• W1671132870 hasConceptScore W1671132870C55493867 @default.

• next