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- W16712708 abstract "One of the first roles assigned to astrocytes was the supply of energetic compounds to neurons, since astrocytes form the first cellular barrier encountered by glucose as it enters the brain. This metabolic role of astrocytes may be played by single and independent astrocytes, but a characteristic feature of astrocytes is communication through intercellular gap junctions. Since these intercellular channels allow diffusion of molecules between adjacent cells, it seems more likely that functionally coupled astrocytes are involved in metabolic trafficking. The aim of this article is to put together the evidence obtained so far, regarding diffusion of metabolic substrates through astrocytic gap junctions, in support of this hypothesis. In addition, the focus is on the effects on glucose uptake and metabolism of disrupting gap junctional communication, and the relationship this may have with proliferation." @default.
- W16712708 created "2016-06-24" @default.
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- W16712708 date "2009-01-01" @default.
- W16712708 modified "2023-10-03" @default.
- W16712708 title "Gap Junctions: Metabolic Exchanges" @default.
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- W16712708 doi "https://doi.org/10.1016/b978-008045046-9.01730-7" @default.
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