Matches in SemOpenAlex for { <https://semopenalex.org/work/W167132144> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W167132144 endingPage "240" @default.
- W167132144 startingPage "240" @default.
- W167132144 abstract "4-Aminopyridine reverses the inhibitory effect produced by crotoxin on the depolarization induced by carbachol. This chapter discusses a study to examine the effect of 4-aminopyridme on the desensitization of the rat diaphragm caused by carbachol. In this study, the experiments were carried out in the isolated rat diaphragm. The measurement of transmembrane potential was done with glass microelectrodes filled with 3 M KCl using standard techniques. Desensitization was induced by adding carbachol to the Tyrode solution bathing the preparation. 4-Aminopyridine was added either before carbachol or after it when the end-plates repolarized in spite of the presence of carbachol in the bath. In the experiments in which 4-aminopyridine was added before carbachol, the agonist produced permanent depolarization, that is, 4-aminopyridine prevented desensitization of the receptors. When it was added after repolarization, the end-plates depolarized to the same extent as before desensitization. It was concluded through the study that 4-aminopyridine has the unique property of stabilizing the receptors of end-plate in the undesensitized state, reversing them to the state when they are already desensitized." @default.
- W167132144 created "2016-06-24" @default.
- W167132144 creator A5002058333 @default.
- W167132144 creator A5050387069 @default.
- W167132144 date "1982-01-01" @default.
- W167132144 modified "2023-10-03" @default.
- W167132144 title "Effect of 4-Aminopyridine on the Desensitisation of the Rat Diaphragm Caused by Carbachol" @default.
- W167132144 cites W2004497536 @default.
- W167132144 doi "https://doi.org/10.1016/b978-0-08-028000-4.50052-x" @default.
- W167132144 hasPublicationYear "1982" @default.
- W167132144 type Work @default.
- W167132144 sameAs 167132144 @default.
- W167132144 citedByCount "0" @default.
- W167132144 crossrefType "book-chapter" @default.
- W167132144 hasAuthorship W167132144A5002058333 @default.
- W167132144 hasAuthorship W167132144A5050387069 @default.
- W167132144 hasConcept C12554922 @default.
- W167132144 hasConcept C170493617 @default.
- W167132144 hasConcept C185592680 @default.
- W167132144 hasConcept C2778988552 @default.
- W167132144 hasConcept C2779779143 @default.
- W167132144 hasConcept C2780922449 @default.
- W167132144 hasConcept C4141045 @default.
- W167132144 hasConcept C55493867 @default.
- W167132144 hasConcept C71924100 @default.
- W167132144 hasConcept C83743174 @default.
- W167132144 hasConcept C86803240 @default.
- W167132144 hasConcept C98274493 @default.
- W167132144 hasConceptScore W167132144C12554922 @default.
- W167132144 hasConceptScore W167132144C170493617 @default.
- W167132144 hasConceptScore W167132144C185592680 @default.
- W167132144 hasConceptScore W167132144C2778988552 @default.
- W167132144 hasConceptScore W167132144C2779779143 @default.
- W167132144 hasConceptScore W167132144C2780922449 @default.
- W167132144 hasConceptScore W167132144C4141045 @default.
- W167132144 hasConceptScore W167132144C55493867 @default.
- W167132144 hasConceptScore W167132144C71924100 @default.
- W167132144 hasConceptScore W167132144C83743174 @default.
- W167132144 hasConceptScore W167132144C86803240 @default.
- W167132144 hasConceptScore W167132144C98274493 @default.
- W167132144 hasLocation W1671321441 @default.
- W167132144 hasOpenAccess W167132144 @default.
- W167132144 hasPrimaryLocation W1671321441 @default.
- W167132144 hasRelatedWork W1926988878 @default.
- W167132144 hasRelatedWork W1965351729 @default.
- W167132144 hasRelatedWork W1966652955 @default.
- W167132144 hasRelatedWork W1974003908 @default.
- W167132144 hasRelatedWork W1976308073 @default.
- W167132144 hasRelatedWork W2001098717 @default.
- W167132144 hasRelatedWork W2002733374 @default.
- W167132144 hasRelatedWork W2005367904 @default.
- W167132144 hasRelatedWork W2018071029 @default.
- W167132144 hasRelatedWork W2044777260 @default.
- W167132144 hasRelatedWork W2051112750 @default.
- W167132144 hasRelatedWork W2057002993 @default.
- W167132144 hasRelatedWork W2058530714 @default.
- W167132144 hasRelatedWork W2061007479 @default.
- W167132144 hasRelatedWork W2077980339 @default.
- W167132144 hasRelatedWork W2080991314 @default.
- W167132144 hasRelatedWork W2124945742 @default.
- W167132144 hasRelatedWork W2164422500 @default.
- W167132144 hasRelatedWork W2183188414 @default.
- W167132144 hasRelatedWork W568565399 @default.
- W167132144 isParatext "false" @default.
- W167132144 isRetracted "false" @default.
- W167132144 magId "167132144" @default.
- W167132144 workType "book-chapter" @default.