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- W1671422017 abstract "Germ line development is crucial in organisms with sexual reproduction to complete their life cycle. In mammals, knowledge about germ line development is based mainly on the mouse model, in which genetic and epigenetic events are well described. However, little is known about how germ line development is orchestrated in humans, especially in the earliest stages. New findings derived from human in vitro models to obtain germ cells can shed light on these questions. This comprehensive review summarizes the current knowledge about mammalian germ line development, emphasizing the state of the art obtained from in vitro models for germ cell-like cell derivation. Current knowledge of the pluripotency cycle and germ cell specification has allowed different in vitro strategies to obtain germ cells with proven functionality in mouse models. Several reports during the last 10 years show that in vitro germ cell derivation with proven functionality to generate a healthy offspring is possible in mice. However, differences in the embryo development and pluripotency potential between human and mouse make it difficult to extrapolate these results. Further efforts on both human and mouse in vitro models to obtain germ cells from pluripotent stem cells may help to elucidate how human physiological events take place; therefore, therapeutic strategies can also be considered." @default.
- W1671422017 created "2016-06-24" @default.
- W1671422017 creator A5013619332 @default.
- W1671422017 creator A5027057730 @default.
- W1671422017 creator A5049099761 @default.
- W1671422017 creator A5051501047 @default.
- W1671422017 creator A5057906482 @default.
- W1671422017 date "2015-09-15" @default.
- W1671422017 modified "2023-09-23" @default.
- W1671422017 title "Understanding Mammalian Germ Line Development with In Vitro Models" @default.
- W1671422017 cites W1580908187 @default.
- W1671422017 cites W1587973507 @default.
- W1671422017 cites W1589189765 @default.
- W1671422017 cites W1646817159 @default.
- W1671422017 cites W1911209928 @default.
- W1671422017 cites W1915101347 @default.
- W1671422017 cites W1966541202 @default.
- W1671422017 cites W1968550191 @default.
- W1671422017 cites W1977135603 @default.
- W1671422017 cites W1981323595 @default.
- W1671422017 cites W1982429165 @default.
- W1671422017 cites W1984397592 @default.
- W1671422017 cites W1988643971 @default.
- W1671422017 cites W1996676239 @default.
- W1671422017 cites W1998763321 @default.
- W1671422017 cites W1998841413 @default.
- W1671422017 cites W1999478022 @default.
- W1671422017 cites W2006169630 @default.
- W1671422017 cites W2007003847 @default.
- W1671422017 cites W2011458783 @default.
- W1671422017 cites W2015138787 @default.
- W1671422017 cites W2016942099 @default.
- W1671422017 cites W2016971867 @default.
- W1671422017 cites W2019007991 @default.
- W1671422017 cites W2021306295 @default.
- W1671422017 cites W2021528928 @default.
- W1671422017 cites W2022049388 @default.
- W1671422017 cites W2022924863 @default.
- W1671422017 cites W2023844789 @default.
- W1671422017 cites W2024992399 @default.
- W1671422017 cites W2026529460 @default.
- W1671422017 cites W2030978758 @default.
- W1671422017 cites W2031416354 @default.
- W1671422017 cites W2033218458 @default.
- W1671422017 cites W2038752568 @default.
- W1671422017 cites W2043622843 @default.
- W1671422017 cites W2045899482 @default.
- W1671422017 cites W2047445181 @default.
- W1671422017 cites W2049298656 @default.
- W1671422017 cites W2052844968 @default.
- W1671422017 cites W2057018960 @default.
- W1671422017 cites W2057159461 @default.
- W1671422017 cites W2059145054 @default.
- W1671422017 cites W2059528261 @default.
- W1671422017 cites W2061126642 @default.
- W1671422017 cites W2062211740 @default.
- W1671422017 cites W2065746091 @default.
- W1671422017 cites W2067102637 @default.
- W1671422017 cites W2068351971 @default.
- W1671422017 cites W2071295503 @default.
- W1671422017 cites W2071365780 @default.
- W1671422017 cites W2073453074 @default.
- W1671422017 cites W2074857302 @default.
- W1671422017 cites W2077536265 @default.
- W1671422017 cites W2082091416 @default.
- W1671422017 cites W2082547435 @default.
- W1671422017 cites W2084434640 @default.
- W1671422017 cites W2088128367 @default.
- W1671422017 cites W2090260381 @default.
- W1671422017 cites W2099189400 @default.
- W1671422017 cites W2099943594 @default.
- W1671422017 cites W2101994612 @default.
- W1671422017 cites W2103210980 @default.
- W1671422017 cites W2105219855 @default.
- W1671422017 cites W2105241566 @default.
- W1671422017 cites W2109546355 @default.
- W1671422017 cites W2110737932 @default.
- W1671422017 cites W2118722608 @default.
- W1671422017 cites W2126590649 @default.
- W1671422017 cites W2127530271 @default.
- W1671422017 cites W2132277188 @default.
- W1671422017 cites W2133036785 @default.
- W1671422017 cites W2133652052 @default.
- W1671422017 cites W2134349183 @default.
- W1671422017 cites W2136063036 @default.
- W1671422017 cites W2136191371 @default.
- W1671422017 cites W2137232121 @default.
- W1671422017 cites W2140017455 @default.
- W1671422017 cites W2141737525 @default.
- W1671422017 cites W2142482111 @default.
- W1671422017 cites W2142514820 @default.
- W1671422017 cites W2142594935 @default.
- W1671422017 cites W2143023822 @default.
- W1671422017 cites W2145296283 @default.
- W1671422017 cites W2146939258 @default.
- W1671422017 cites W2152589171 @default.
- W1671422017 cites W2155870354 @default.
- W1671422017 cites W2159584345 @default.
- W1671422017 cites W2160983947 @default.
- W1671422017 cites W2161604785 @default.