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- W1671460941 abstract "Primary cilia are ubiquitous mammalian cellular substructures implicated in an ever-increasing number of regulatory pathways. The well-established ciliary hypothesis states that physical bending of the cilium (for example, due to fluid flow) initiates signaling cascades, yet the mechanical properties of the cilium remain incompletely measured, resulting in confusion regarding the biological significance of flow-induced ciliary mechanotransduction. In this work we measure the mechanical properties of a primary cilium by using an optical trap to induce resonant oscillation of the structure. Our data indicate 1) the primary cilium is not a simple cantilevered beam; 2) the base of the cilium may be modeled as a nonlinear rotatory spring, with the linear spring constant k of the cilium base calculated to be (4.6 ± 0.62) × 10(-12) N/rad and nonlinear spring constant α to be (-1 ± 0.34) × 10(-10) N/rad(2); and 3) the ciliary base may be an essential regulator of mechanotransduction signaling. Our method is also particularly suited to measure mechanical properties of nodal cilia, stereocilia, and motile cilia-anatomically similar structures with very different physiological functions." @default.
- W1671460941 created "2016-06-24" @default.
- W1671460941 creator A5081152594 @default.
- W1671460941 date "2015-07-01" @default.
- W1671460941 modified "2023-09-28" @default.
- W1671460941 title "Mechanical Properties of a Primary Cilium As Measured by Resonant Oscillation" @default.
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- W1671460941 doi "https://doi.org/10.1016/j.bpj.2015.05.031" @default.
- W1671460941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4572495" @default.
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- W1671460941 hasPublicationYear "2015" @default.
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