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• W1671720437 endingPage "2416" @default.
• W1671720437 startingPage "2388" @default.
• W1671720437 abstract "The maintenance of genomic integrity is an important process in organisms as failure to sense and repair damaged DNA can result in a variety of diseases. Eukaryotic cells have developed complex DNA repair response (DDR) mechanisms to accurately sense and repair damaged DNA. Post-translational modifications by ubiquitin and ubiquitin-like proteins, such as SUMO and NEDD8, have roles in coordinating the progression of DDR. Proteins in the neddylation pathway have also been linked to regulating DDR. Of interest is the COP9 signalosome (CSN), a multi-subunit metalloprotease present in eukaryotes that removes NEDD8 from cullins and regulates the activity of cullin-RING ubiquitin ligases (CRLs). This in turn regulates the stability and turnover of a host of CRL-targeted proteins, some of which have established roles in DDR. This review will summarize the current knowledge on the role of the CSN and neddylation in DNA repair." @default.
• W1671720437 created "2016-06-24" @default.
• W1671720437 creator A5025409534 @default.
• W1671720437 creator A5078364744 @default.
• W1671720437 date "2015-09-30" @default.
• W1671720437 modified "2023-10-13" @default.
• W1671720437 title "The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair" @default.
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