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- W1671891078 abstract "Ins(1,4,5)P3 is a classical intracellular messenger: stimulus-dependent changes in its levels elicits biological effects through its release of intracellular Ca2+ stores. The Ins(1,4,5)P3 response is “switched off” by its metabolism to a range of additional inositol phosphates. These metabolites have themselves come to be collectively described as a signaling “family”. The validity of that latter definition is critically examined in this review. That is, we assess the strength of the hypothesis that Ins(1,4,5)P3 metabolites are themselves “classical” signals. Put another way, what is the evidence that the biological function of a particular inositol phosphate depends upon stimulus dependent changes in its levels? In this assessment, examples of an inositol phosphate acting as a cofactor (i.e. its function is not stimulus-dependent) do not satisfy our signaling criteria. We conclude that Ins(3,4,5,6)P4 is, to date, the only Ins(1,4,5)P3 metabolite that has been validated to act as a second messenger." @default.
- W1671891078 created "2016-06-24" @default.
- W1671891078 creator A5013107971 @default.
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- W1671891078 date "2012-01-01" @default.
- W1671891078 modified "2023-10-03" @default.
- W1671891078 title "Defining Signal Transduction by Inositol Phosphates" @default.
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