FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1671927486> ?p ?o ?g. }

• W1671927486 endingPage "1308" @default.
• W1671927486 startingPage "1300" @default.
• W1671927486 abstract "Human embryonic stem cells (hESCs) can proliferate extensively in culture and give rise to progeny of the three germ layers. Several reports suggested that mouse and hESCs may attenuate immune responses. In this study, we focused on the mechanism by which hESCs inhibit T cell responses. Using coculture experiments, we demonstrate that hESCs inhibit cytokine secretion and T cell proliferation in response to potent T cell activators. Furthermore, we show that hESCs downmodulate the TCR-associated CD3-zeta chain. These effects are maintained when hESCs are replaced by their conditioned media and can be restored by the addition of L-arginine to hESC-conditioned media or by treatment of hESCs with a specific arginase inhibitor. Moreover, we show arginase-I expression and activity in hESCs. We further demonstrate that mouse ESCs (mESCs) similarly inhibit T cell activation via arginase I, suggesting an evolutionary conserved mechanism of T cell suppression by ESCs. In addition, we demonstrate that arginase I expression is not limited to ESCs in culture, but can also be detected in the inner cell mass and the trophectoderm of preimplantation mouse embryos and hESC-derived trophectoderm cells. Finally, T cells infiltrating ESC-derived teratomas have significantly lower levels of CD3-zeta chain. Collectively, the data indicate a role for ESC-arginase I activity in the attenuation of T cell activation." @default.
• W1671927486 created "2016-06-24" @default.
• W1671927486 creator A5035365163 @default.
• W1671927486 creator A5058749953 @default.
• W1671927486 creator A5062643514 @default.
• W1671927486 creator A5079028501 @default.
• W1671927486 creator A5088375056 @default.
• W1671927486 date "2009-12-23" @default.
• W1671927486 modified "2023-10-12" @default.
• W1671927486 title "Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism" @default.
• W1671927486 cites W1832992073 @default.
• W1671927486 cites W1905007654 @default.
• W1671927486 cites W1970302905 @default.
• W1671927486 cites W1977179270 @default.
• W1671927486 cites W1994471614 @default.
• W1671927486 cites W1998792937 @default.
• W1671927486 cites W2006712783 @default.
• W1671927486 cites W2026638749 @default.
• W1671927486 cites W2027295876 @default.
• W1671927486 cites W2034293734 @default.
• W1671927486 cites W2056089399 @default.
• W1671927486 cites W2067950819 @default.
• W1671927486 cites W2071898475 @default.
• W1671927486 cites W2086943348 @default.
• W1671927486 cites W2133014598 @default.
• W1671927486 cites W2136502698 @default.
• W1671927486 cites W2138281334 @default.
• W1671927486 cites W2138442302 @default.
• W1671927486 cites W2139133344 @default.
• W1671927486 cites W2149437353 @default.
• W1671927486 cites W2151517892 @default.
• W1671927486 cites W2154637790 @default.
• W1671927486 cites W2170122868 @default.
• W1671927486 cites W2218611209 @default.
• W1671927486 cites W2409577509 @default.
• W1671927486 doi "https://doi.org/10.4049/jimmunol.0804261" @default.
• W1671927486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20032293" @default.
• W1671927486 hasPublicationYear "2009" @default.
• W1671927486 type Work @default.
• W1671927486 sameAs 1671927486 @default.
• W1671927486 citedByCount "49" @default.
• W1671927486 countsByYear W16719274862012 @default.
• W1671927486 countsByYear W16719274862013 @default.
• W1671927486 countsByYear W16719274862014 @default.
• W1671927486 countsByYear W16719274862015 @default.
• W1671927486 countsByYear W16719274862016 @default.
• W1671927486 countsByYear W16719274862017 @default.
• W1671927486 countsByYear W16719274862018 @default.
• W1671927486 countsByYear W16719274862019 @default.
• W1671927486 countsByYear W16719274862020 @default.
• W1671927486 countsByYear W16719274862021 @default.
• W1671927486 countsByYear W16719274862022 @default.
• W1671927486 countsByYear W16719274862023 @default.
• W1671927486 crossrefType "journal-article" @default.
• W1671927486 hasAuthorship W1671927486A5035365163 @default.
• W1671927486 hasAuthorship W1671927486A5058749953 @default.
• W1671927486 hasAuthorship W1671927486A5062643514 @default.
• W1671927486 hasAuthorship W1671927486A5079028501 @default.
• W1671927486 hasAuthorship W1671927486A5088375056 @default.
• W1671927486 hasBestOaLocation W16719274861 @default.
• W1671927486 hasConcept C104317684 @default.
• W1671927486 hasConcept C114684123 @default.
• W1671927486 hasConcept C145103041 @default.
• W1671927486 hasConcept C148738053 @default.
• W1671927486 hasConcept C1491633281 @default.
• W1671927486 hasConcept C153911025 @default.
• W1671927486 hasConcept C159399396 @default.
• W1671927486 hasConcept C164007495 @default.
• W1671927486 hasConcept C167672396 @default.
• W1671927486 hasConcept C196843134 @default.
• W1671927486 hasConcept C203014093 @default.
• W1671927486 hasConcept C2776090121 @default.
• W1671927486 hasConcept C2777468819 @default.
• W1671927486 hasConcept C2778177303 @default.
• W1671927486 hasConcept C515207424 @default.
• W1671927486 hasConcept C55493867 @default.
• W1671927486 hasConcept C86803240 @default.
• W1671927486 hasConcept C87073359 @default.
• W1671927486 hasConcept C8891405 @default.
• W1671927486 hasConcept C95444343 @default.
• W1671927486 hasConceptScore W1671927486C104317684 @default.
• W1671927486 hasConceptScore W1671927486C114684123 @default.
• W1671927486 hasConceptScore W1671927486C145103041 @default.
• W1671927486 hasConceptScore W1671927486C148738053 @default.
• W1671927486 hasConceptScore W1671927486C1491633281 @default.
• W1671927486 hasConceptScore W1671927486C153911025 @default.
• W1671927486 hasConceptScore W1671927486C159399396 @default.
• W1671927486 hasConceptScore W1671927486C164007495 @default.
• W1671927486 hasConceptScore W1671927486C167672396 @default.
• W1671927486 hasConceptScore W1671927486C196843134 @default.
• W1671927486 hasConceptScore W1671927486C203014093 @default.
• W1671927486 hasConceptScore W1671927486C2776090121 @default.
• W1671927486 hasConceptScore W1671927486C2777468819 @default.
• W1671927486 hasConceptScore W1671927486C2778177303 @default.
• W1671927486 hasConceptScore W1671927486C515207424 @default.
• W1671927486 hasConceptScore W1671927486C55493867 @default.
• W1671927486 hasConceptScore W1671927486C86803240 @default.
• W1671927486 hasConceptScore W1671927486C87073359 @default.

• next