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• W1672070115 abstract "Introduction. We previously showed that in HNF1A-MODY the cystatin C-based glomerular filtration rate (GFR) estimate is higher than the creatinine-based estimate. Currently, we aimed to replicate this finding and verify its clinical significance. Methods. The study included 72 patients with HNF1A-MODY, 72 with GCK-MODY, 53 with type 1 diabetes (T1DM), 70 with type 2 diabetes (T2DM), and 65 controls. Serum creatinine and cystatin C levels were measured. GFR was calculated from creatinine and cystatin C using the CKD-EPI creatinine equation (eGRF-cr) and CKD-EPI cystatin C equation (eGFR-cys), respectively. Results. Cystatin C levels were lower (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.001</mml:mn></mml:math>) in the control (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn fontstyle=italic>0.70</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.13</mml:mn></mml:math> mg/L), HNF1A (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mn fontstyle=italic>0.75</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.21</mml:mn></mml:math>), and GCK (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn fontstyle=italic>0.72</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.16</mml:mn></mml:math> mg/L) groups in comparison to those with either T1DM (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mn fontstyle=italic>0.87</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.15</mml:mn></mml:math> mg/L) or T2DM (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mn fontstyle=italic>0.9</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.23</mml:mn></mml:math> mg/L). Moreover, eGFR-cys was higher than eGRF-cr in HNF1A-MODY, GCK-MODY, and the controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.004</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.003</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.0001</mml:mn></mml:math>). This corresponded to 8.9 mL/min/1.73 m 2 , 9.7 mL/min/1.73 m 2 , and 16.9 mL/min/1.73 m 2 of difference. Additionally, T1DM patients had higher eGFR-cr than eGFR-cys (11.6 mL/min/1.73 m 2 ; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.0004</mml:mn></mml:math>); no difference occurred in T2DM (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.91</mml:mn></mml:math>). Conclusions. We confirmed that eGFR-cys values in HNF1A-MODY patients are higher compared to eGFR-cr. Some other differences were also described in diabetic groups. However, none of them appears to be clinically relevant." @default.
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• W1672070115 date "2015-01-01" @default.
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• W1672070115 title "Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes" @default.
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• W1672070115 doi "https://doi.org/10.1155/2015/183094" @default.
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