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• W1672236927 abstract "In a study with 24 Beagle puppies receiving diets with and without fat (lard) for 6 to 7 months after weaning, it was found that the distribution of the fatty acids in erythrocytes and in plasma was influenced by the level of the caloric intake in the following respects. The dienoic and tetraenoic acids were low in the red blood cells and plasma in the animals fed the low-fat diets as compared with the control animals that were fed fat. At the high caloric intakes the levels for both di- and tetraenoic acids were always less (cells and plasma) with and without fat than at the low caloric intakes. Dienoic acid levels were always lower in cells than in plasma whereas tetraenoic acid levels were consistently greater in cells than in plasma. Trienoic acid levels were higher in blood cells and plasma in the absence of dietary fat. The level of this fatty acid in the fat-deficient state was proportional to the caloric intake. When fat was lacking in the diets there was little difference in levels between the cells and plasma, whereas in the control animals receiving fat no trienoic acid was found in the red cells. Palmitoleic and oleic acids were higher in plasma and blood cells of the animals fed the low-fat diet than in the control group. These levels were high in plasma compared with blood cells, irrespective of caloric intake. The saturated fatty acids (palmitic and stearic) were not altered significantly by caloric intake or level of fat in the diet. Stearic acid was higher in blood cells than in plasma. In both red cells and plasma definite changes in the amounts of the di- tri- and tetraenoic acids in fat-deficient animals were evident as early as two to three months of feeding time. Dienoic acids decreased greatly but the drop was more marked at the high caloric level. Increases in trienoic acids were directly proportional to the caloric intake, whereas the levels for tetraenoic acids were inversely proportional to the caloric intake. The magnitude of changes in tri- and tetraenoic acids at two to three months was greater in plasma than in cells. It was concluded from study of the serum lipids in the fat-deficient state that the dienoic acid levels of both cells and plasma are reliable indices of the dietary lack of linoleic acid. Moreover, the synthesis of trienoic acid and of tetraenoic acid are influenced remarkedly by the caloric intake and the resulting rate of growth; hence, they are also of value in interpreting degrees of deficiency." @default.
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• W1672236927 date "1962-10-01" @default.
• W1672236927 modified "2023-10-04" @default.
• W1672236927 title "Effect of Diets with and without Fat at Low and High Caloric Levels on Fatty Acids in Blood Cells and Plasma of Dogs" @default.
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• W1672236927 doi "https://doi.org/10.1093/jn/78.2.167" @default.
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