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- W1672912759 abstract "To study radiobiological effects and drugs, which can modify radiation injury, has an importance if we would like to avoid harmful effects of radiation due to emergency situations or treat patients with malignant diseases by radiotherapy. During the long treatment schedules patients may be treated by not only anticancer but many other drugs because of accompanying diseases. These drugs may also modify radiobiological effects. Rosiglitazone pre‐treatment proved to be myeloprotective and accelerated recovery of 5‐fluorouracil‐damaged bone marrow in our previous experiments. Our new studies are designed to evaluate whether rosiglitazone has similar beneficial effects in radiation‐damaged hemopoiesis. Bone marrow damage was precipitated by total body irradiation (TBI) using single increasing doses (2–10 Gy) of γ—irradiation in groups of mice. Lethality was well correlated with damage in hemopoiesis measured by cellularity of bone marrow (LD50 values were 4.8 and 5.3 gray respectively). Rosiglitazone, an insulin‐sensitizing drug, had no significant effect on bone marrow cellularity. Insulin resistance associated with obesity or diabetes mellitus type 2 is intensively growing among cancer patients requiring some kind of radiotherapy. Therefore it is important to know whether drugs used for their therapy can modify radiation effects." @default.
- W1672912759 created "2016-06-24" @default.
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- W1672912759 date "2008-01-01" @default.
- W1672912759 modified "2023-10-18" @default.
- W1672912759 title "Effect of Rosiglitazone on Radiation Damage in Bone Marrow Hemopoiesis" @default.
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- W1672912759 doi "https://doi.org/10.1063/1.3058979" @default.
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