FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1672954108> ?p ?o ?g. }

• W1672954108 endingPage "259" @default.
• W1672954108 startingPage "250" @default.
• W1672954108 abstract "High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is released passively during cell injury and necrosis, and secreted actively by immune cells. HMGB1 contains three conserved redox-sensitive cysteine residues: C23 and C45 can form an intramolecular disulfide bond, whereas C106 is unpaired and is essential for the interaction with Toll-Like Receptor (TLR) 4. However, a comprehensive characterization of the dynamic redox states of each cysteine residue and of their impacts on innate immune responses is lacking. Using tandem mass spectrometric analysis, we now have established that the C106 thiol and the C23-C45 disulfide bond are required for HMGB1 to induce nuclear NF-κB translocation and tumor necrosis factor (TNF) production in macrophages. Both irreversible oxidation to sulphonates and complete reduction to thiols of these cysteines inhibited TNF production markedly. In a proof of concept murine model of hepatic necrosis induced by acetaminophen, during inflammation, the predominant form of serum HMGB1 is the active one, containing a C106 thiol group and a disulfide bond between C23 and C45, whereas the inactive form of HMGB1, containing terminally oxidized cysteines, accumulates during inflammation resolution and hepatic regeneration. These results reveal critical posttranslational redox mechanisms that control the proinflammatory activity of HMGB1 and its inactivation during pathogenesis." @default.
• W1672954108 created "2016-06-24" @default.
• W1672954108 creator A5004532503 @default.
• W1672954108 creator A5010564587 @default.
• W1672954108 creator A5017563247 @default.
• W1672954108 creator A5034647715 @default.
• W1672954108 creator A5064483920 @default.
• W1672954108 creator A5073475874 @default.
• W1672954108 creator A5075168559 @default.
• W1672954108 creator A5075492017 @default.
• W1672954108 creator A5078542779 @default.
• W1672954108 creator A5078561745 @default.
• W1672954108 date "2011-11-07" @default.
• W1672954108 modified "2023-10-18" @default.
• W1672954108 title "Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)" @default.
• W1672954108 cites W1541957757 @default.
• W1672954108 cites W1926551934 @default.
• W1672954108 cites W1931590068 @default.
• W1672954108 cites W1973404097 @default.
• W1672954108 cites W1981311979 @default.
• W1672954108 cites W1981868658 @default.
• W1672954108 cites W1997054462 @default.
• W1672954108 cites W2004266769 @default.
• W1672954108 cites W2014758051 @default.
• W1672954108 cites W2029068688 @default.
• W1672954108 cites W2052919564 @default.
• W1672954108 cites W2059072962 @default.
• W1672954108 cites W2084623259 @default.
• W1672954108 cites W2104414795 @default.
• W1672954108 cites W2114242405 @default.
• W1672954108 cites W2142365299 @default.
• W1672954108 cites W2144578574 @default.
• W1672954108 cites W2151277012 @default.
• W1672954108 cites W2152022294 @default.
• W1672954108 cites W2158924104 @default.
• W1672954108 cites W2161788422 @default.
• W1672954108 cites W2164714222 @default.
• W1672954108 cites W2171028311 @default.
• W1672954108 cites W2206714426 @default.
• W1672954108 doi "https://doi.org/10.2119/molmed.2011.00389" @default.
• W1672954108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7772900" @default.
• W1672954108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33380312" @default.
• W1672954108 hasPublicationYear "2011" @default.
• W1672954108 type Work @default.
• W1672954108 sameAs 1672954108 @default.
• W1672954108 citedByCount "357" @default.
• W1672954108 countsByYear W16729541082012 @default.
• W1672954108 countsByYear W16729541082013 @default.
• W1672954108 countsByYear W16729541082014 @default.
• W1672954108 countsByYear W16729541082015 @default.
• W1672954108 countsByYear W16729541082016 @default.
• W1672954108 countsByYear W16729541082017 @default.
• W1672954108 countsByYear W16729541082018 @default.
• W1672954108 countsByYear W16729541082019 @default.
• W1672954108 countsByYear W16729541082020 @default.
• W1672954108 countsByYear W16729541082021 @default.
• W1672954108 countsByYear W16729541082022 @default.
• W1672954108 countsByYear W16729541082023 @default.
• W1672954108 crossrefType "journal-article" @default.
• W1672954108 hasAuthorship W1672954108A5004532503 @default.
• W1672954108 hasAuthorship W1672954108A5010564587 @default.
• W1672954108 hasAuthorship W1672954108A5017563247 @default.
• W1672954108 hasAuthorship W1672954108A5034647715 @default.
• W1672954108 hasAuthorship W1672954108A5064483920 @default.
• W1672954108 hasAuthorship W1672954108A5073475874 @default.
• W1672954108 hasAuthorship W1672954108A5075168559 @default.
• W1672954108 hasAuthorship W1672954108A5075492017 @default.
• W1672954108 hasAuthorship W1672954108A5078542779 @default.
• W1672954108 hasAuthorship W1672954108A5078561745 @default.
• W1672954108 hasBestOaLocation W16729541081 @default.
• W1672954108 hasConcept C136449434 @default.
• W1672954108 hasConcept C164027704 @default.
• W1672954108 hasConcept C170493617 @default.
• W1672954108 hasConcept C17991360 @default.
• W1672954108 hasConcept C181199279 @default.
• W1672954108 hasConcept C185592680 @default.
• W1672954108 hasConcept C203014093 @default.
• W1672954108 hasConcept C2776709828 @default.
• W1672954108 hasConcept C2776914184 @default.
• W1672954108 hasConcept C2778690821 @default.
• W1672954108 hasConcept C2779201268 @default.
• W1672954108 hasConcept C2780545709 @default.
• W1672954108 hasConcept C55493867 @default.
• W1672954108 hasConcept C86803240 @default.
• W1672954108 hasConcept C95444343 @default.
• W1672954108 hasConceptScore W1672954108C136449434 @default.
• W1672954108 hasConceptScore W1672954108C164027704 @default.
• W1672954108 hasConceptScore W1672954108C170493617 @default.
• W1672954108 hasConceptScore W1672954108C17991360 @default.
• W1672954108 hasConceptScore W1672954108C181199279 @default.
• W1672954108 hasConceptScore W1672954108C185592680 @default.
• W1672954108 hasConceptScore W1672954108C203014093 @default.
• W1672954108 hasConceptScore W1672954108C2776709828 @default.
• W1672954108 hasConceptScore W1672954108C2776914184 @default.
• W1672954108 hasConceptScore W1672954108C2778690821 @default.
• W1672954108 hasConceptScore W1672954108C2779201268 @default.
• W1672954108 hasConceptScore W1672954108C2780545709 @default.
• W1672954108 hasConceptScore W1672954108C55493867 @default.

• next