Matches in SemOpenAlex for { <https://semopenalex.org/work/W1674361195> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1674361195 endingPage "40" @default.
- W1674361195 startingPage "2336" @default.
- W1674361195 abstract "Recently, a human homologue of the Drosophila patched gene, PTCH, was identified as a putative tumor suppressor mutated in both hereditary and sporadic basal cell carcinomas. Because PTCH controls its own transcription, inactivating mutations in PTCH may lead to overexpression of mutant PTCH mRNA due to loss of autoregulation. The present study is aimed at evaluating whether deregulation of PTCH mRNA expression is a general feature of BCCs of varying histological growth pattern and malignant potential. Irrespective of histological subtype, PTCH mRNA was overexpressed consistently as determined by in situ hybridization in all of the sporadic (n = 16) and hereditary (n = 20) tumors examined. PTCH expression was found in all of the tumor cells but appeared stronger in the peripheral palisading cells. PTCH mRNA was not detected in adjacent nontumor epidermal cells or in other parts of the epidermis. In the majority of tumors (20 of 36), nuclear immunostaining for p53 was found in scattered cells, whereas seven tumors completely lacked p53 immunoreactivity. Our finding of an up-regulation of PTCH mRNA levels in all of the BCCs analyzed indicates that deregulation of the PTCH signaling pathway constitutes an early rate-limiting event in BCC development." @default.
- W1674361195 created "2016-06-24" @default.
- W1674361195 creator A5004455626 @default.
- W1674361195 creator A5012104864 @default.
- W1674361195 creator A5042257111 @default.
- W1674361195 creator A5051537868 @default.
- W1674361195 creator A5056645286 @default.
- W1674361195 date "1997-06-15" @default.
- W1674361195 modified "2023-10-16" @default.
- W1674361195 title "Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma." @default.
- W1674361195 cites W1515905084 @default.
- W1674361195 cites W1550806320 @default.
- W1674361195 cites W1980591242 @default.
- W1674361195 cites W2036698724 @default.
- W1674361195 cites W2044616474 @default.
- W1674361195 cites W2056994384 @default.
- W1674361195 cites W2093531978 @default.
- W1674361195 cites W2127001212 @default.
- W1674361195 cites W2165469800 @default.
- W1674361195 cites W2409662602 @default.
- W1674361195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9192803" @default.
- W1674361195 hasPublicationYear "1997" @default.
- W1674361195 type Work @default.
- W1674361195 sameAs 1674361195 @default.
- W1674361195 citedByCount "42" @default.
- W1674361195 countsByYear W16743611952013 @default.
- W1674361195 countsByYear W16743611952014 @default.
- W1674361195 countsByYear W16743611952015 @default.
- W1674361195 countsByYear W16743611952017 @default.
- W1674361195 countsByYear W16743611952018 @default.
- W1674361195 countsByYear W16743611952019 @default.
- W1674361195 countsByYear W16743611952020 @default.
- W1674361195 crossrefType "journal-article" @default.
- W1674361195 hasAuthorship W1674361195A5004455626 @default.
- W1674361195 hasAuthorship W1674361195A5012104864 @default.
- W1674361195 hasAuthorship W1674361195A5042257111 @default.
- W1674361195 hasAuthorship W1674361195A5051537868 @default.
- W1674361195 hasAuthorship W1674361195A5056645286 @default.
- W1674361195 hasConcept C104317684 @default.
- W1674361195 hasConcept C105580179 @default.
- W1674361195 hasConcept C142724271 @default.
- W1674361195 hasConcept C203014093 @default.
- W1674361195 hasConcept C204232928 @default.
- W1674361195 hasConcept C2777994357 @default.
- W1674361195 hasConcept C2778804307 @default.
- W1674361195 hasConcept C3019992690 @default.
- W1674361195 hasConcept C4224716 @default.
- W1674361195 hasConcept C502942594 @default.
- W1674361195 hasConcept C54355233 @default.
- W1674361195 hasConcept C71924100 @default.
- W1674361195 hasConcept C81439078 @default.
- W1674361195 hasConcept C86803240 @default.
- W1674361195 hasConcept C88498014 @default.
- W1674361195 hasConceptScore W1674361195C104317684 @default.
- W1674361195 hasConceptScore W1674361195C105580179 @default.
- W1674361195 hasConceptScore W1674361195C142724271 @default.
- W1674361195 hasConceptScore W1674361195C203014093 @default.
- W1674361195 hasConceptScore W1674361195C204232928 @default.
- W1674361195 hasConceptScore W1674361195C2777994357 @default.
- W1674361195 hasConceptScore W1674361195C2778804307 @default.
- W1674361195 hasConceptScore W1674361195C3019992690 @default.
- W1674361195 hasConceptScore W1674361195C4224716 @default.
- W1674361195 hasConceptScore W1674361195C502942594 @default.
- W1674361195 hasConceptScore W1674361195C54355233 @default.
- W1674361195 hasConceptScore W1674361195C71924100 @default.
- W1674361195 hasConceptScore W1674361195C81439078 @default.
- W1674361195 hasConceptScore W1674361195C86803240 @default.
- W1674361195 hasConceptScore W1674361195C88498014 @default.
- W1674361195 hasIssue "12" @default.
- W1674361195 hasLocation W16743611951 @default.
- W1674361195 hasOpenAccess W1674361195 @default.
- W1674361195 hasPrimaryLocation W16743611951 @default.
- W1674361195 hasRelatedWork W1674361195 @default.
- W1674361195 hasRelatedWork W2046465935 @default.
- W1674361195 hasRelatedWork W2050352061 @default.
- W1674361195 hasRelatedWork W2064073941 @default.
- W1674361195 hasRelatedWork W2078105292 @default.
- W1674361195 hasRelatedWork W2136934871 @default.
- W1674361195 hasRelatedWork W2293812545 @default.
- W1674361195 hasRelatedWork W2315813623 @default.
- W1674361195 hasRelatedWork W3134028762 @default.
- W1674361195 hasRelatedWork W3148636477 @default.
- W1674361195 hasVolume "57" @default.
- W1674361195 isParatext "false" @default.
- W1674361195 isRetracted "false" @default.
- W1674361195 magId "1674361195" @default.
- W1674361195 workType "article" @default.