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• W1674691036 endingPage "835" @default.
• W1674691036 startingPage "827" @default.
• W1674691036 abstract "Spontaneous mutators of Salmonella typhimurium LT2 were generated by inserting the transposable element Tn5 or Tn10 into the bacterial chromosome. Two mutators mapped at the position of the mutH and mutL loci of S. typhimurium, and two other mutators mapped at positions corresponding to the mutS and uvrD loci of Escherichia coli. A fifth mutator, mutB, did not map at a position corresponding to any of the known mutators of S. typhimurium or E. coli. The mutH,L,S and uvrD alleles increased the frequency of both spontaneous base substitution and frameshift mutations, whereas the mutB allele increased the frequency only of spontaneous base substitution mutations. The increased frequency of base substitution mutations was recA+ independent in the mutH, mutL, and uvrD strains and partially recA+ independent in the mutS strain. The uvrD mutation decreased the resistance of the cells to killing by ultraviolet irradiation. The mutH,L,S and uvrD strains showed an increased sensitivity to mutagenesis by the alkylating agents methyl methane sulfonate and ethyl methane sulfonate, but not to mutagenesis by 4-nitroquinoline-1-oxide." @default.
• W1674691036 created "2016-06-24" @default.
• W1674691036 creator A5008216710 @default.
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• W1674691036 date "1981-09-01" @default.
• W1674691036 modified "2023-09-26" @default.
• W1674691036 title "Spontaneous mutators of salmonella typhimurium LT2 generated by insertion of transposable elements" @default.
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• W1674691036 doi "https://doi.org/10.1128/jb.147.3.827-835.1981" @default.
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• W1674691036 hasPublicationYear "1981" @default.
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