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• W167476085 abstract "p63, a transcription factor related to the p53 tumor suppressor, plays a key role in epidermal differentiation and limb development. The gene has two distinct promoters that allow the formation of proteins that either contain (TA) or lack (ΔN) a transactivation domain. ΔNp63α is the most widely expressed isoform, at all stages of development and in adult tissues. It supports the regenerative capacity of basal keratinocytes and its upregulation is a hallmark of human squamous carcinomas. To get insight into the complex biology of ΔNp63α, we set out to identify ΔNp63α interacting proteins by co-immunoprecipitation in mammalian cells and mass spectrometry analysis. A total of 49 potential ΔNp63α binding proteins, including several heterogeneous ribonucleoproteins (hnRNPs), were identified. Integration of the proteomic data with a Human Coexpression Network highlighted 5 putative p63 protein interactors whose expression is significantly comodulated with p63: hnRNPA/B, hnRNPK, hnRNPQ, FUS/TLS and Keratin 5. hnRNPA/B was already described as a p63 partner, but the others were novel. Interaction of ΔNp63α with hnRNPQ, hnRNPK and FUS/TLS was confirmed by reciprocal co-immunoprecipitations in human keratinocytes. The finding that ΔNp63α exists in complexes with several RNA-binding proteins lays the premises for the analysis of the role of ΔNp63α in mRNA metabolism and transport." @default.
• W167476085 created "2016-06-24" @default.
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• W167476085 date "2010-02-04" @default.
• W167476085 modified "2023-10-17" @default.
• W167476085 title "Identification of ΔNp63α Protein Interactions by Mass Spectrometry" @default.
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• W167476085 doi "https://doi.org/10.1021/pr9011156" @default.
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