FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1675192013> ?p ?o ?g. }

• W1675192013 endingPage "37" @default.
• W1675192013 startingPage "625" @default.
• W1675192013 abstract "Repeatedly bred male and female rats develop arteriosclerosis spontaneously. Despite hyperlipidaemia, fatty liver and obesity the arterial lesions contain minuscule quantities of lipid. Because histopathological lipid techniques may not detect bound or “masked” lipid, we used thin layer chromatography, which affords extra sensitivity in detecting small quantities of lipids. A survey was made of the lipids in female breeder aortae on the basis of the severity of their grossly-visible arteriosclerosis. The aortae were divided into arch, thoracic and abdominal aortic segments to further delineate any lipid changes, according to the anatomical pathogenesis of the arterial disease. Adrenal lipid changes were also analysed by the TLC procedure, comparing adrenal glands of non-arteriosclerotic animals with those having severe, grossly visible arteriosclerosis.The TLC method demonstrated that small quantities of lipid accumulate in the aortae of repeatedly bred rats, first in the abdominal aortic segment, increasing in concentration with progressive severity of arteriosclerosis and spreading from abdominal aorta to arch and thoracic aorta. Specifically, phospholipids, free fatty acids, cholesterol, di- and triglycerides are increased whereas cholesterol ester is decreased as arteriosclerosis becomes more advanced. Adrenocortical di- and triglycerides were found to be greatly increased in those animals having severe, grossly visible arteriosclerosis. However, total cholesterol was reduced. These adrenal lipid changes are construed to be a reflection of the eventual impairment of the steroidogenic capacity of arteriosclerotic breeder rats. Our conclusions are that the stimulation of the hypothalamic-pituitary-adrenal-gonadal axis occasioned by repeated breeding invokes first a condition of hyperadrenocorticism, followed by adrenal “exhaustion”. The excess adrenal (and gonadal) steroids condition these animals towards hyperlipidaemia, fatty metamorphosis of the liver and obesity. However, these endogenous lipid changes do not contribute directly to the pathogenesis of the arterial lesions." @default.
• W1675192013 created "2016-06-24" @default.
• W1675192013 creator A5026264295 @default.
• W1675192013 creator A5086356690 @default.
• W1675192013 date "1972-12-01" @default.
• W1675192013 modified "2023-09-23" @default.
• W1675192013 title "Comparison of aortic and adrenal glandular lipids between non-arteriosclerotic and arteriosclerotic rats." @default.
• W1675192013 cites W1971643620 @default.
• W1675192013 cites W1978884304 @default.
• W1675192013 cites W2002049000 @default.
• W1675192013 cites W2018964047 @default.
• W1675192013 cites W2021380148 @default.
• W1675192013 cites W2022418759 @default.
• W1675192013 cites W2037839564 @default.
• W1675192013 cites W2044110335 @default.
• W1675192013 cites W2047054700 @default.
• W1675192013 cites W2073854752 @default.
• W1675192013 cites W2081242789 @default.
• W1675192013 cites W2130768177 @default.
• W1675192013 cites W2143782683 @default.
• W1675192013 cites W2157413239 @default.
• W1675192013 cites W2168526937 @default.
• W1675192013 cites W2169672723 @default.
• W1675192013 cites W2204125127 @default.
• W1675192013 cites W2322387214 @default.
• W1675192013 cites W2460750523 @default.
• W1675192013 cites W2418356544 @default.
• W1675192013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2072498" @default.
• W1675192013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4646198" @default.
• W1675192013 hasPublicationYear "1972" @default.
• W1675192013 type Work @default.
• W1675192013 sameAs 1675192013 @default.
• W1675192013 citedByCount "3" @default.
• W1675192013 crossrefType "journal-article" @default.
• W1675192013 hasAuthorship W1675192013A5026264295 @default.
• W1675192013 hasAuthorship W1675192013A5086356690 @default.
• W1675192013 hasConcept C126322002 @default.
• W1675192013 hasConcept C134018914 @default.
• W1675192013 hasConcept C142724271 @default.
• W1675192013 hasConcept C2776393769 @default.
• W1675192013 hasConcept C2776864027 @default.
• W1675192013 hasConcept C2778163477 @default.
• W1675192013 hasConcept C2779980429 @default.
• W1675192013 hasConcept C2780520971 @default.
• W1675192013 hasConcept C2781285907 @default.
• W1675192013 hasConcept C4733338 @default.
• W1675192013 hasConcept C71924100 @default.
• W1675192013 hasConceptScore W1675192013C126322002 @default.
• W1675192013 hasConceptScore W1675192013C134018914 @default.
• W1675192013 hasConceptScore W1675192013C142724271 @default.
• W1675192013 hasConceptScore W1675192013C2776393769 @default.
• W1675192013 hasConceptScore W1675192013C2776864027 @default.
• W1675192013 hasConceptScore W1675192013C2778163477 @default.
• W1675192013 hasConceptScore W1675192013C2779980429 @default.
• W1675192013 hasConceptScore W1675192013C2780520971 @default.
• W1675192013 hasConceptScore W1675192013C2781285907 @default.
• W1675192013 hasConceptScore W1675192013C4733338 @default.
• W1675192013 hasConceptScore W1675192013C71924100 @default.
• W1675192013 hasIssue "6" @default.
• W1675192013 hasLocation W16751920131 @default.
• W1675192013 hasOpenAccess W1675192013 @default.
• W1675192013 hasPrimaryLocation W16751920131 @default.
• W1675192013 hasRelatedWork W1675192013 @default.
• W1675192013 hasRelatedWork W1971049036 @default.
• W1675192013 hasRelatedWork W2021013879 @default.
• W1675192013 hasRelatedWork W2058741369 @default.
• W1675192013 hasRelatedWork W2061319657 @default.
• W1675192013 hasRelatedWork W2077291389 @default.
• W1675192013 hasRelatedWork W2088745575 @default.
• W1675192013 hasRelatedWork W2292843536 @default.
• W1675192013 hasRelatedWork W2365614881 @default.
• W1675192013 hasRelatedWork W3144664614 @default.
• W1675192013 hasVolume "53" @default.
• W1675192013 isParatext "false" @default.
• W1675192013 isRetracted "false" @default.
• W1675192013 magId "1675192013" @default.
• W1675192013 workType "article" @default.