FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1675910794> ?p ?o ?g. }

• W1675910794 endingPage "704" @default.
• W1675910794 startingPage "693" @default.
• W1675910794 abstract "In colon cancer, K-Ras oncogenes, which appear to be linked to chemoresistance and poor prognosis, are activated in more than 50% of cases, whereas the tumor suppressor gene p53 is mutationally altered in about 70% of all cases. The transcription factor p53, which is frequently mutated at codon 273, maintains wild-type configuration and possibly carries out residual functions. Although blocking of activated K-Ras may constitute a rational therapeutic concept for this treatment-resistant malignancy, a strategy influencing both oncogenic Ras and the tumor suppressor p53 may be even more promising.We evaluated the effects of S-trans, trans-farnesyl-thiosalicylic acid (FTS), a novel Ras antagonist on human SW480 and HT-29 colon cancer cells, which both harbor a p53 His273 mutation but express activated K-Ras and wild-type, but overexpressed, H-Ras, respectively. Besides cell growth and morphology, levels of cellular Ras proteins, regulation of p53 and p21(waf1/cip1) expression were analyzed by immunoblotting. The cell cycle arresting potential of FTS was quantified by flow cytometry.We demonstrate that FTS treatment alters the morphology and blocks the growth of SW480 and HT-29 colon cancer cells by both reducing the total amount of Ras and up-regulating the tumor suppressor p53. Furthermore, FTS caused an upregulation of the cyclin-cyclin-dependent kinase (CDK) inhibitor p21(waf1/cip1) and blocked the cell cycle. p53 antisense oligonucleotides not only reduced the level of p53 proteins but correspondingly also blocked the expression of p21(waf1/cip1) in FTS-treated colon cancer cells.FTS, a unique compound capable of regulating both oncogenic Ras and the tumor suppressor p53 may prove particularly useful for the therapy of colon cancer and other treatment-resistant malignancies where Ras is altered and p53 is either wild-type or mutated in positions that allow residual p53 functions." @default.
• W1675910794 created "2016-06-24" @default.
• W1675910794 creator A5009244604 @default.
• W1675910794 creator A5010783083 @default.
• W1675910794 creator A5031629093 @default.
• W1675910794 creator A5043737654 @default.
• W1675910794 creator A5056905219 @default.
• W1675910794 creator A5061365291 @default.
• W1675910794 date "2000-08-01" @default.
• W1675910794 modified "2023-10-15" @default.
• W1675910794 title "A Novel Ras Antagonist Regulates Both Oncogenic Ras and the Tumor Suppressor p53 in Colon Cancer Cells" @default.
• W1675910794 cites W1545398558 @default.
• W1675910794 cites W1922148398 @default.
• W1675910794 cites W1973800266 @default.
• W1675910794 cites W1975702431 @default.
• W1675910794 cites W1990750680 @default.
• W1675910794 cites W1991992481 @default.
• W1675910794 cites W1992295617 @default.
• W1675910794 cites W2001503989 @default.
• W1675910794 cites W2003282728 @default.
• W1675910794 cites W2008506563 @default.
• W1675910794 cites W2014318158 @default.
• W1675910794 cites W2015519364 @default.
• W1675910794 cites W2018129810 @default.
• W1675910794 cites W2019820356 @default.
• W1675910794 cites W2030231219 @default.
• W1675910794 cites W2034092995 @default.
• W1675910794 cites W2036048603 @default.
• W1675910794 cites W2040876807 @default.
• W1675910794 cites W2051626784 @default.
• W1675910794 cites W2051958366 @default.
• W1675910794 cites W2053670125 @default.
• W1675910794 cites W2054224954 @default.
• W1675910794 cites W2054549064 @default.
• W1675910794 cites W2056454654 @default.
• W1675910794 cites W2059185804 @default.
• W1675910794 cites W2059244758 @default.
• W1675910794 cites W2068803638 @default.
• W1675910794 cites W2070061120 @default.
• W1675910794 cites W2070633770 @default.
• W1675910794 cites W2071697240 @default.
• W1675910794 cites W2075300416 @default.
• W1675910794 cites W2079207880 @default.
• W1675910794 cites W2081290278 @default.
• W1675910794 cites W2086532812 @default.
• W1675910794 cites W2087213997 @default.
• W1675910794 cites W2088032374 @default.
• W1675910794 cites W2089218510 @default.
• W1675910794 cites W2090576400 @default.
• W1675910794 cites W2101301592 @default.
• W1675910794 cites W2104978230 @default.
• W1675910794 cites W2107666634 @default.
• W1675910794 cites W2127952872 @default.
• W1675910794 cites W2147887491 @default.
• W1675910794 cites W2159072093 @default.
• W1675910794 cites W2223661640 @default.
• W1675910794 cites W2323231231 @default.
• W1675910794 cites W2327259869 @default.
• W1675910794 cites W2333809012 @default.
• W1675910794 doi "https://doi.org/10.1007/bf03402049" @default.
• W1675910794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1949977" @default.
• W1675910794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11055588" @default.
• W1675910794 hasPublicationYear "2000" @default.
• W1675910794 type Work @default.
• W1675910794 sameAs 1675910794 @default.
• W1675910794 citedByCount "43" @default.
• W1675910794 countsByYear W16759107942012 @default.
• W1675910794 countsByYear W16759107942013 @default.
• W1675910794 countsByYear W16759107942014 @default.
• W1675910794 countsByYear W16759107942015 @default.
• W1675910794 countsByYear W16759107942016 @default.
• W1675910794 countsByYear W16759107942017 @default.
• W1675910794 countsByYear W16759107942021 @default.
• W1675910794 countsByYear W16759107942022 @default.
• W1675910794 crossrefType "journal-article" @default.
• W1675910794 hasAuthorship W1675910794A5009244604 @default.
• W1675910794 hasAuthorship W1675910794A5010783083 @default.
• W1675910794 hasAuthorship W1675910794A5031629093 @default.
• W1675910794 hasAuthorship W1675910794A5043737654 @default.
• W1675910794 hasAuthorship W1675910794A5056905219 @default.
• W1675910794 hasAuthorship W1675910794A5061365291 @default.
• W1675910794 hasBestOaLocation W16759107941 @default.
• W1675910794 hasConcept C121608353 @default.
• W1675910794 hasConcept C124320809 @default.
• W1675910794 hasConcept C153911025 @default.
• W1675910794 hasConcept C2778264664 @default.
• W1675910794 hasConcept C2781018059 @default.
• W1675910794 hasConcept C29537977 @default.
• W1675910794 hasConcept C502942594 @default.
• W1675910794 hasConcept C54355233 @default.
• W1675910794 hasConcept C555283112 @default.
• W1675910794 hasConcept C86803240 @default.
• W1675910794 hasConcept C96232424 @default.
• W1675910794 hasConceptScore W1675910794C121608353 @default.
• W1675910794 hasConceptScore W1675910794C124320809 @default.
• W1675910794 hasConceptScore W1675910794C153911025 @default.
• W1675910794 hasConceptScore W1675910794C2778264664 @default.
• W1675910794 hasConceptScore W1675910794C2781018059 @default.

• next