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- W167593273 abstract "Growth hormone receptor (GHR) is a transmembrane protein encoded by a gene mapped on cattle chromosome 20, which mediates the growth hormone (GH) action in different tissues. In cattle, a T/A substitution located in exon 8, which causes a p.Phe279Tyr in the transmembrane domain of GHR, was associated with higher protein and fat percentages of milk. In an effort to better understand the possible influence of this polymorphism on mammary gland development and function in cattle, we have comparatively studied the frequency this polymorphism on two groups of cattle. The first group was composed of Romanian Black and White (RBW) breed dams, Holstein type, characterised by well developed mammary gland and high milk yield and the second group was composed of Romanian Grey Steppe (RGS) Moldavian strain dams, an ancestral breed characterized by poorly developed mammary gland and very low milk yield, but with higher milk quality as regards protein and fat contents. Surprisingly we found that in RGS breed T allele (Phe) had the highest frequency (T=1), while in RBW breed the calculated frequencies were (T=0.773, A=0.227). Based on the observed frequencies and literature data, according to which A allele (Tyr) was associated with higher milk quality, we concluded that mutations in one gene cannot explain the variability of milk production traits in these two extreme breeds." @default.
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- W167593273 date "2013-01-01" @default.
- W167593273 modified "2023-09-27" @default.
- W167593273 title "Polymorphism within growth hormone receptor (GHR) gene in Romanian Black and White and Romanian Grey Steppe cattle breeds." @default.
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