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- W1675962022 abstract "While neuronal cell types display an astounding degree of phenotypic diversity, most if not all neuron types share a core panel of terminal features. However, little is known about how pan-neuronal expression patterns are genetically programmed. Through an extensive analysis of the cis-regulatory control regions of a battery of pan-neuronal C. elegans genes, including genes involved in synaptic vesicle biology and neuropeptide signaling, we define a common organizational principle in the regulation of pan-neuronal genes in the form of a surprisingly complex array of seemingly redundant, parallel-acting cis-regulatory modules that direct expression to broad, overlapping domains throughout the nervous system. These parallel-acting cis-regulatory modules are responsive to a multitude of distinct trans-acting factors. Neuronal gene expression programs therefore fall into two fundamentally distinct classes. Neuron-type-specific genes are generally controlled by discrete and non-redundantly acting regulatory inputs, while pan-neuronal gene expression is controlled by diverse, coincident and seemingly redundant regulatory inputs." @default.
- W1675962022 created "2016-06-24" @default.
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- W1675962022 date "2015-08-01" @default.
- W1675962022 modified "2023-10-18" @default.
- W1675962022 title "Regulatory Logic of Pan-Neuronal Gene Expression in C. elegans" @default.
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- W1675962022 doi "https://doi.org/10.1016/j.neuron.2015.07.031" @default.
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