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- W167620054 abstract "Axonal flow serves as an indicator and measure in the dynamics of neuron. This chapter presents the phenomenon of axonal flow in this broader perspective, with the aim of combining aspects gained by various specialized techniques into a unified picture. The usage of the simple term axonal flow itself carries a risk—the risk of oversimplification, unrealistic interpretations, and premature overextension. Axonal flow is a cell-biological phenomenon characteristic of a cell of peculiar constitution, the neuron. The peculiarity of that cell lies in its usual possession of enormous elongations and in the resulting extreme eccentricity of the site of the nucleus and its surrounding cytoplasmic mass—the perikaryon. In the molecular communities of most other cells, the processes of synthesis, macromolecular assemblage, internal transport, catabolic breakdown, and elimination of metabolites and cell products are so grossly intermingled that they are difficult to separate. Similarly, the neuron used to be taken for granted as a cell in which anabolic and catabolic processes go on ubiquitously. Axonal flow has radically changed that notion by demonstrating that in the neuron, the major production site of cellular constituents and the area of their consumption are not intermingled and coextensive but are rather neatly segregated, which necessarily requires an organized traffic system from source to consumers—and this is exactly what axonal flow provides." @default.
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- W167620054 date "1969-01-01" @default.
- W167620054 modified "2023-10-10" @default.
- W167620054 title "NEURONAL DYNAMICS AND NEUROPLASMIC (“AXONAL”) FLOW" @default.
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- W167620054 doi "https://doi.org/10.1016/b978-0-12-611908-4.50006-x" @default.
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