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- W1676258214 abstract "We conducted a literature review about renal posttransplantation diabetes mellitus (PTDM), a glucose metabolism alteration with high incidence. Immunosuppressive therapy, by different diabetogenic mechanisms, is the major risk factor for PTDM. Although corticosteroids and calcineurin inhibitors are the drugs most related to PTDM, the mechanisms of other drugs have been also investigated. Available data in the literature show that, in renal transplant patients, the oral glucose tolerance test presents the highest diagnostic sensitivity for PTDM, although fasting plasma glucose is the most requested test. In addition, we also discussed the possible role of hemoglobin A1C in the diagnosis of PTDM. Renal PTDM is associated with patient survival reduction, increased cardiovascular mortality and has been linked to worsening graft function. As crucial as the screening, the accurate management of the disease can ameliorate graft and patient survival as well as the quality of life of this especial population. Several drugs have been studied in PTDM patients in order to achieve a better glycemic control and, in the best scenario, prevent PTDM. We present proper management approaches that should help to reduce the possible long-term consequences of PTDM." @default.
- W1676258214 created "2016-06-24" @default.
- W1676258214 creator A5017419846 @default.
- W1676258214 creator A5025285429 @default.
- W1676258214 creator A5075852757 @default.
- W1676258214 date "2015-10-01" @default.
- W1676258214 modified "2023-09-25" @default.
- W1676258214 title "Renal posttransplantation diabetes mellitus: An overview" @default.
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- W1676258214 doi "https://doi.org/10.1016/j.cca.2015.09.010" @default.
- W1676258214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26368267" @default.