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- W1676608665 abstract "Abstract In an attempt to design antitumour cyclophosphazenes of improved specificity by linking them to some natural tumour finders, we studied the binding of gem -N 3 P 3 Az 4 Cl 2 to spermine. Synthesis, NMR and mass spectra of the vectorized drug (in which two N 3 P 3 Az 4 active principles are linked to spermine in a DISPIROBINO configuration) are described. Results obtained with this compound in 6 murine tumour systems (L1210 and P388 leukaemias, 3LL carcinoma, M5076 reticulum cell sarcoma, B16 melanoma and line 16 mammary carcinoma), are also described and compared with results previously obtained about the targeting of gem -N 3 P 3 Az 4 Cl 2 through 1,3-diaminopropane and 1,4-diaminobutane (putrescine)." @default.
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- W1676608665 date "1986-09-01" @default.
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- W1676608665 title "Attempts at the production of more selective antitumourals" @default.
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- W1676608665 doi "https://doi.org/10.1016/0022-2860(86)87067-3" @default.
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