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• W1676981804 abstract "Oxidative stress has generally been recognized as an important factor in the pathogenesis of human diseases, making antioxidant therapy a plausible strategy to either prevent or treat human disorders. Yet so far, numerous antioxidant-based clinical trials aimed at developing clinically approved protocols have been disappointing and many reasons for their failure are being discussed, including the limited bioavailability of most antioxidants. To overcome the hurdles associated with the direct administration of antioxidant molecules, a variety of nanotechnology-based drug delivery systems are being developed. All the strategies currently being explored, however, appear in our opinion to underappreciate the crucial role reactive oxygen and nitrogen species (RO/NS) play in the regulation of the metabolome, as revealed by recent progress made in redox biology.We briefly review antioxidant-based clinical trials and discuss the functions of RO/NS as crucial intracellular messengers. We emphasize the probable existence of three distinct concentration levels of RO/NS: a physiological level reflecting their functions as messenger molecules, an elevated level crucial for activation of protective pathways and a toxic level causing oxidative damage to cellular components.Site-specific, multifunctional nanodrug delivery systems able to sense the actual intracellular concentrations of RO/NS and release antioxidants accordingly in order to only neutralize the pathologic excess of RO/NS need to be developed." @default.
• W1676981804 created "2016-06-24" @default.
• W1676981804 creator A5004125816 @default.
• W1676981804 creator A5034000086 @default.
• W1676981804 date "2015-06-29" @default.
• W1676981804 modified "2023-10-17" @default.
• W1676981804 title "Nanocarrier-based antioxidant therapy: promise or delusion?" @default.
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• W1676981804 doi "https://doi.org/10.1517/17425247.2015.1063611" @default.
• W1676981804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26119920" @default.
• W1676981804 hasPublicationYear "2015" @default.
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