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- W1677881169 abstract "In this study, two types of biodegradable polycation (PAsp(DET) homopolymer and PEG-PAsp(DET) copolymer) were applied as vectors for inhalable dry gene powders prepared by spray freeze drying (SFD). The prepared dry gene powders had spherical and porous structures with a 5~10-μm diameter, and the integrity of plasmid DNA could be maintained during powder production. Furthermore, it was clarified that PEG-PAsp(DET)-based dry gene powder could more sufficiently maintain both the physicochemical properties and in vitro gene transfection efficiencies of polyplexes reconstituted after powder production than PAsp(DET)-based dry gene powder. From an in vitro inhalation study using an Andersen cascade impactor, it was demonstrated that the addition of l-leucine could markedly improve the inhalation performance of dry powders prepared by SFD. Following pulmonary delivery to mice, both PAsp(DET)- and PEG-PAsp(DET)-based dry gene powders could achieve higher gene transfection efficiencies in the lungs compared with a chitosan-based dry gene powder previously reported by us." @default.
- W1677881169 created "2016-06-24" @default.
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- W1677881169 date "2015-08-26" @default.
- W1677881169 modified "2023-10-14" @default.
- W1677881169 title "Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying" @default.
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- W1677881169 doi "https://doi.org/10.3390/pharmaceutics7030233" @default.
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