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- W1678304730 endingPage "2055" @default.
- W1678304730 startingPage "2044" @default.
- W1678304730 abstract "Protein kinase D1 (PKD1) is expressed ubiquitously and regulates diverse cellular processes such as oxidative stress, gene expression, cell survival, and vesicle trafficking. However, the presence and function of PKD1 in monocytic cells are currently unknown. In this study, we provide evidence that PKD1 is involved in TLR9 signaling in macrophages. Class B-type CpG DNA (CpG-B DNA) induced activation of PKD1 via a pathway that is dependent on endosomal pH, TLR9, MyD88, and IL-1R-associated kinase 1 in macrophages. Upon CpG-B DNA stimulation, PKD1 interacted with the TLR9/MyD88/IL-1R-associated kinase/TNFR-associated factor 6 complex. Knockdown of PKD1 revealed that PKD1 is required for activation of NF-kappaB and MAPKs, and subsequent expression of cytokines in response to CpG-B DNA. Our findings identify PKD1 as a key signaling modulator in TLR9-mediated macrophage activation." @default.
- W1678304730 created "2016-06-24" @default.
- W1678304730 creator A5003266453 @default.
- W1678304730 creator A5008065253 @default.
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- W1678304730 date "2008-07-18" @default.
- W1678304730 modified "2023-10-05" @default.
- W1678304730 title "Protein Kinase D1: A New Component in TLR9 Signaling" @default.
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- W1678304730 doi "https://doi.org/10.4049/jimmunol.181.3.2044" @default.
- W1678304730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2587394" @default.
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