Matches in SemOpenAlex for { <https://semopenalex.org/work/W1678531335> ?p ?o ?g. }
- W1678531335 endingPage "6830" @default.
- W1678531335 startingPage "6819" @default.
- W1678531335 abstract "Reactivation of CMV can cause severe disease after allogeneic hemopoietic stem cell transplantation. Adoptive T cell therapy was successfully used for patients who had received transplants from CMV-positive donors. However, patients with transplants from CMV-negative donors are at highest risk, and an adoptive therapy is missing because CMV-specific T cells are not available from such donors. To address this problem, we used retroviral transfer of CMV-specific TCR genes. We generated CMV-specific T cell clones of several HLA restrictions recognizing the endogenously processed Ag pp65. The genes of four TCRs were cloned and transferred to primary T cells from CMV-negative donors. These CMV-TCR-transgenic T cells displayed a broad spectrum of important effector functions (secretion of IFN-gamma and IL-2, cytotoxicity, proliferation) in response to endogenously processed pp65 and could be enriched and expanded by strictly Ag-specific stimulation. Expansion of engineered T cells was accompanied by an increase in specific effector functions, indicating that the transferred specificity is stable and fully functional. Hence, we expect these CMV-TCR-transgenic T cells to be effective in controlling acute CMV disease and establishing an antiviral memory." @default.
- W1678531335 created "2016-06-24" @default.
- W1678531335 creator A5000579890 @default.
- W1678531335 creator A5045431644 @default.
- W1678531335 creator A5054447908 @default.
- W1678531335 creator A5090277402 @default.
- W1678531335 date "2009-11-15" @default.
- W1678531335 modified "2023-10-08" @default.
- W1678531335 title "CMV-Specific TCR-Transgenic T Cells for Immunotherapy" @default.
- W1678531335 cites W1480489408 @default.
- W1678531335 cites W1598317500 @default.
- W1678531335 cites W1895052014 @default.
- W1678531335 cites W1963942217 @default.
- W1678531335 cites W196757896 @default.
- W1678531335 cites W1972936356 @default.
- W1678531335 cites W1975040998 @default.
- W1678531335 cites W1978297661 @default.
- W1678531335 cites W1981480494 @default.
- W1678531335 cites W1989550920 @default.
- W1678531335 cites W1993721428 @default.
- W1678531335 cites W1993858544 @default.
- W1678531335 cites W2003974082 @default.
- W1678531335 cites W2009607549 @default.
- W1678531335 cites W2018886802 @default.
- W1678531335 cites W2029909479 @default.
- W1678531335 cites W2034149373 @default.
- W1678531335 cites W2054394975 @default.
- W1678531335 cites W2060096554 @default.
- W1678531335 cites W2060813063 @default.
- W1678531335 cites W2061644646 @default.
- W1678531335 cites W2064796142 @default.
- W1678531335 cites W2074503110 @default.
- W1678531335 cites W2076919967 @default.
- W1678531335 cites W2080025346 @default.
- W1678531335 cites W2084286364 @default.
- W1678531335 cites W2094652659 @default.
- W1678531335 cites W2103734212 @default.
- W1678531335 cites W2103849595 @default.
- W1678531335 cites W2105381977 @default.
- W1678531335 cites W2113603236 @default.
- W1678531335 cites W2114358743 @default.
- W1678531335 cites W2115176597 @default.
- W1678531335 cites W2115356035 @default.
- W1678531335 cites W2119627739 @default.
- W1678531335 cites W2120535481 @default.
- W1678531335 cites W2123440147 @default.
- W1678531335 cites W2124989514 @default.
- W1678531335 cites W2129659050 @default.
- W1678531335 cites W2135511012 @default.
- W1678531335 cites W2138567003 @default.
- W1678531335 cites W2141550316 @default.
- W1678531335 cites W2153549003 @default.
- W1678531335 cites W2156248061 @default.
- W1678531335 cites W2159305020 @default.
- W1678531335 cites W2159975194 @default.
- W1678531335 cites W2161911625 @default.
- W1678531335 cites W2161934945 @default.
- W1678531335 cites W2161944139 @default.
- W1678531335 cites W2162787845 @default.
- W1678531335 cites W2168957744 @default.
- W1678531335 cites W40694895 @default.
- W1678531335 cites W4254711666 @default.
- W1678531335 doi "https://doi.org/10.4049/jimmunol.0902233" @default.
- W1678531335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19864595" @default.
- W1678531335 hasPublicationYear "2009" @default.
- W1678531335 type Work @default.
- W1678531335 sameAs 1678531335 @default.
- W1678531335 citedByCount "77" @default.
- W1678531335 countsByYear W16785313352012 @default.
- W1678531335 countsByYear W16785313352013 @default.
- W1678531335 countsByYear W16785313352014 @default.
- W1678531335 countsByYear W16785313352015 @default.
- W1678531335 countsByYear W16785313352016 @default.
- W1678531335 countsByYear W16785313352017 @default.
- W1678531335 countsByYear W16785313352018 @default.
- W1678531335 countsByYear W16785313352019 @default.
- W1678531335 countsByYear W16785313352020 @default.
- W1678531335 countsByYear W16785313352021 @default.
- W1678531335 countsByYear W16785313352022 @default.
- W1678531335 countsByYear W16785313352023 @default.
- W1678531335 crossrefType "journal-article" @default.
- W1678531335 hasAuthorship W1678531335A5000579890 @default.
- W1678531335 hasAuthorship W1678531335A5045431644 @default.
- W1678531335 hasAuthorship W1678531335A5054447908 @default.
- W1678531335 hasAuthorship W1678531335A5090277402 @default.
- W1678531335 hasBestOaLocation W16785313351 @default.
- W1678531335 hasConcept C102230213 @default.
- W1678531335 hasConcept C104317684 @default.
- W1678531335 hasConcept C111599444 @default.
- W1678531335 hasConcept C126322002 @default.
- W1678531335 hasConcept C159047783 @default.
- W1678531335 hasConcept C19317047 @default.
- W1678531335 hasConcept C203014093 @default.
- W1678531335 hasConcept C2776090121 @default.
- W1678531335 hasConcept C2911091166 @default.
- W1678531335 hasConcept C51785407 @default.
- W1678531335 hasConcept C54355233 @default.
- W1678531335 hasConcept C71924100 @default.