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- W1678794328 abstract "Host responses elicited by type IV secretion systems (T4SS) activity are important factors in determining whether the infection will be resolved or whether bacteria will be able to cause a persistent infection. This chapter discusses recent findings on the functions of T4SS of Legionella pneumophila , Helicobacter pylori , Bordetella pertussis , Bartonella species, and Brucella species as well as new information gained from animal and cellular models of infection on how the secreted substrates alter the host's response to infection. Legionella species are facultative intracellular pathogens found ubiquitously in freshwater environments, where they invade and replicate within amoebae and other protozoa. Importantly, NF- κB translocation is essential for the intracellular survival of Legionella , as the inhibition of this process resulted in the death of infected cells and prevented further bacterial replication when macrophages were infected at a low multiplicity of infection in a previous study. Studies of the global transcriptional response of gastric epithelial cells to H. pylori infection have shed light on the contribution of the T4SS to chronic inflammation and gastric cancer. Although the Dot/Icm T4SS transfers DNA by conjugation in vitro, it is not known whether DNA can be translocated into host cells during L. pneumophila infection. The popularity of employing T4SS for host-pathogen interaction may be due in part to the fact that these virulence factors can accommodate the secretion of distinct sets of effector proteins, thereby enabling each pathogen to adapt to a different specific niche." @default.
- W1678794328 created "2016-06-24" @default.
- W1678794328 creator A5041615993 @default.
- W1678794328 creator A5054787075 @default.
- W1678794328 date "2007-08-15" @default.
- W1678794328 modified "2023-10-05" @default.
- W1678794328 title "Type IV Secretion Systems and Their Role in Eliciting Host Responses to Infection" @default.
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