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- W167906392 abstract "The beneficial effects of exercise on vascular endothelium are well established. Previous studies suggest endothelial dysfunction in sedentary (SED) subjects after acute hypertension induced by weight lifting (WL), but not in conditioned weight lifters (CWL). This study tested the hypothesis that: runners are also protected from endothelial dysfunction induced by acute WL; and runners who resistance train (cross training; CT) are similarly protected from exertional endothelial dysfunction. Male, healthy, lean SED subjects, CWL, runners (>15 miles/week), and CT underwent BP measurements during a single progressive leg press weight lifting session (reaching 85% 1RM). Brachial artery (BA) flow- mediated vasodilation (FMD) was determined with ultrasound immediately before and after weight lifting. Nitroglycerin (NTG; 0.4 mg) was used to determine endothelium independent dilation. The BP responses to WL were similar (max SBP: 199 ± 7 mmHg). Baseline FMD was lower in CT (4.44 ± 0.3%) than CWL (7.16 ± 0.7%) or SED (7.86 ± 1.3%) but not runners (5.44 ± 0.6%). FMD improved in CWL (8.64 ± 1.0%; p=0.02) and runners (8.04 ± 0.7%; p<0.001) but not CT (5.35 ± 0.6%) after weight lifting. FMD was decreased in SED subjects (5.9 ± 0.5 %; p=0.008) after WL. Dilations to NTG were similar in all groups. BA endothelial function is impaired in SED subjects and improved in runners and CWL after acute WL. FMD in individuals engaged in CT programs is not changed after WL. The protective effect of chronic exercise on endothelial function during acute weight lifting does not appear to be mode specific. Supported by NIH GCRC grant (MO1-RR00058)." @default.
- W167906392 created "2016-06-24" @default.
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- W167906392 date "2007-01-01" @default.
- W167906392 modified "2023-09-26" @default.
- W167906392 title "Resistance and aerobic exercise protects against endothelial dysfunction induced by acute exertion" @default.
- W167906392 doi "https://doi.org/10.1096/fasebj.21.6.a935-a" @default.
- W167906392 hasPublicationYear "2007" @default.
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