FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1679854967> ?p ?o ?g. }

• W1679854967 endingPage "4917" @default.
• W1679854967 startingPage "4917" @default.
• W1679854967 abstract "Phyllanthus amarus (family: Euphorbiaceae) is of immense interest due to its wide spectrum of biological activities. In the present study, the standardized 80% ethanol extract of P. amarus was investigated for its modulatory activity on various cellular immune parameters, including chemotaxis of neutrophils, engulfment of Escherichia coli by neutrophils, and Mac-1 expression, in leukocytes isolated from treated/nontreated Wistar-Kyoto rats. The detailed cell-mediated activity of P. amarus was also investigated, including analysis of the effects on T- and B-cell proliferation and CD4(+) and CD8(+) T-cell subsets in splenic mononuclear cells, and estimation of serum cytokine production by activated T-cells. The main components of the extract, phyllanthin, hypophyllanthin, corilagin, geraniin, ellagic acid, and gallic acid were identified and quantitatively analyzed in the extracts, using validated reversed-phase high-performance liquid chromatography (HPLC) methods. N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced neutrophils isolated from rats administered with the extract of P. amarus, at doses ranging from 100 to 400 mg/kg for 14 days, revealed a significant dose-dependent reduction in neutrophil migration (P<0.05). Similar patterns of inhibition were also observed in phagocytic activity and in fMLP-induced changes in expression of β2 integrin polymorphonuclear neutrophils. The results in P. amarus-treated rats also demonstrated a dose-dependent inhibition of both lipopolysaccharide-stimulated B-cell proliferation and concanavalin A-stimulated T-cell proliferation as compared with sensitized control. At a dose of 400 mg/kg (P<0.01), there was a significant decrease in the (%) expression of CD4(+) and CD8(+) in splenocytes and in serum cytokines of T helper (Th1) (IL-2 and IFN-γ) and Th2 (IL-4). In conclusion, P. amarus showed effective immunosuppressive activities in cellular immune response, by various immune regulatory mechanisms, and may be useful for improvement of immune-related disorders." @default.
• W1679854967 created "2016-06-24" @default.
• W1679854967 creator A5004105099 @default.
• W1679854967 creator A5055739528 @default.
• W1679854967 creator A5067806634 @default.
• W1679854967 creator A5077146717 @default.
• W1679854967 date "2015-08-01" @default.
• W1679854967 modified "2023-10-10" @default.
• W1679854967 title "Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats" @default.
• W1679854967 cites W1225079785 @default.
• W1679854967 cites W1600560134 @default.
• W1679854967 cites W1963858490 @default.
• W1679854967 cites W1964051898 @default.
• W1679854967 cites W1968256995 @default.
• W1679854967 cites W1972922050 @default.
• W1679854967 cites W1974596384 @default.
• W1679854967 cites W1976382588 @default.
• W1679854967 cites W1980008210 @default.
• W1679854967 cites W1980219722 @default.
• W1679854967 cites W1994756072 @default.
• W1679854967 cites W1997103196 @default.
• W1679854967 cites W2008394031 @default.
• W1679854967 cites W2010935162 @default.
• W1679854967 cites W2016734202 @default.
• W1679854967 cites W2017179108 @default.
• W1679854967 cites W2019403290 @default.
• W1679854967 cites W2020075441 @default.
• W1679854967 cites W2020969008 @default.
• W1679854967 cites W2021087192 @default.
• W1679854967 cites W2021363648 @default.
• W1679854967 cites W2027951805 @default.
• W1679854967 cites W2030339633 @default.
• W1679854967 cites W2030617634 @default.
• W1679854967 cites W2032227357 @default.
• W1679854967 cites W2035809865 @default.
• W1679854967 cites W2057758829 @default.
• W1679854967 cites W2067473107 @default.
• W1679854967 cites W2067798288 @default.
• W1679854967 cites W2073940782 @default.
• W1679854967 cites W2074660641 @default.
• W1679854967 cites W2076279611 @default.
• W1679854967 cites W2082427354 @default.
• W1679854967 cites W2087191576 @default.
• W1679854967 cites W2087720890 @default.
• W1679854967 cites W2087841658 @default.
• W1679854967 cites W2088864928 @default.
• W1679854967 cites W2089025855 @default.
• W1679854967 cites W2093670317 @default.
• W1679854967 cites W2096428863 @default.
• W1679854967 cites W2110945615 @default.
• W1679854967 cites W2122560536 @default.
• W1679854967 cites W2132268212 @default.
• W1679854967 cites W2133449490 @default.
• W1679854967 cites W2148013423 @default.
• W1679854967 cites W2157321205 @default.
• W1679854967 cites W2163240674 @default.
• W1679854967 cites W2167360205 @default.
• W1679854967 cites W2171040124 @default.
• W1679854967 cites W41870505 @default.
• W1679854967 cites W4236842068 @default.
• W1679854967 cites W97158386 @default.
• W1679854967 doi "https://doi.org/10.2147/dddt.s88189" @default.
• W1679854967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4555964" @default.
• W1679854967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26347462" @default.
• W1679854967 hasPublicationYear "2015" @default.
• W1679854967 type Work @default.
• W1679854967 sameAs 1679854967 @default.
• W1679854967 citedByCount "15" @default.
• W1679854967 countsByYear W16798549672016 @default.
• W1679854967 countsByYear W16798549672017 @default.
• W1679854967 countsByYear W16798549672018 @default.
• W1679854967 countsByYear W16798549672019 @default.
• W1679854967 countsByYear W16798549672020 @default.
• W1679854967 countsByYear W16798549672021 @default.
• W1679854967 countsByYear W16798549672022 @default.
• W1679854967 countsByYear W16798549672023 @default.
• W1679854967 crossrefType "journal-article" @default.
• W1679854967 hasAuthorship W1679854967A5004105099 @default.
• W1679854967 hasAuthorship W1679854967A5055739528 @default.
• W1679854967 hasAuthorship W1679854967A5067806634 @default.
• W1679854967 hasAuthorship W1679854967A5077146717 @default.
• W1679854967 hasBestOaLocation W16798549671 @default.
• W1679854967 hasConcept C167672396 @default.
• W1679854967 hasConcept C185592680 @default.
• W1679854967 hasConcept C19869320 @default.
• W1679854967 hasConcept C202751555 @default.
• W1679854967 hasConcept C203014093 @default.
• W1679854967 hasConcept C2776718122 @default.
• W1679854967 hasConcept C2778004101 @default.
• W1679854967 hasConcept C2778362808 @default.
• W1679854967 hasConcept C2778754761 @default.
• W1679854967 hasConcept C2781464872 @default.
• W1679854967 hasConcept C55493867 @default.
• W1679854967 hasConcept C556039675 @default.
• W1679854967 hasConcept C62112901 @default.
• W1679854967 hasConcept C70899900 @default.
• W1679854967 hasConcept C71924100 @default.
• W1679854967 hasConcept C86803240 @default.

• next